Tbio RNF187 E3 ubiquitin-protein ligase RNF187

Protein Summary

Description

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Uniprot Accession IDs

• Q5TA31
• A6NL57
• Q6P2J7
• Q6PJR0

Gene Name

• RNF187

Ensembl ID

• ENST00000639044
• ENSP00000492846
• ENSG00000168159
• ENST00000643343
• ENSP00000493929
• ENSG00000285426

Symbol

• RACO1
• RACO-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
transcription factor perturbation	0.8
virus perturbation	0.76
histone modification site profile	0.68
microRNA	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.86   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.86   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0