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Tdark
CCDC18
Coiled-coil domain-containing protein 18

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343253
  • ENSP00000343377
  • ENSG00000122483

Symbol
  • NY-SAR-41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
cell type or tissue
0.74
cell line
0.64
transcription factor binding site profile
0.64
histone modification site profile
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999999978
p_ni:  2.2e-8
Data Source:  BioPlex
COG3
Tbio
Novelty:  0.02746711
p_int:  0.999999975
p_ni:  1.1e-8
p_wrong:  1.4e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999999543
p_ni:  4.57e-7
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999992316
p_ni:  0.000007683
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999988404
p_ni:  0.000011596
Data Source:  BioPlex
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.99984519
p_ni:  0.00015479
p_wrong:  1.9e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999779108
p_ni:  0.000220837
p_wrong:  5.6e-8
Score:  0.664
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999418359
p_ni:  0.000581596
p_wrong:  4.6e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
p_int:  0.963935119
p_ni:  0.006543412
p_wrong:  0.029521469
Score:  0.243
Data Source:  BioPlex,STRINGDB
CCDC14
Tdark
Novelty:  0.62617082
Score:  0.823
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
89.7
high density lipoprotein cholesterol measurement
5
4
7
88.8
eosinophil percentage of leukocytes
2
2
2
86.4
self reported educational attainment
1
1
1
70.5
mathematical ability
2
2
2
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
89.7
high density lipoprotein cholesterol measurement
7
88.8
eosinophil percentage of leukocytes
2
86.4
self reported educational attainment
1
70.5
mathematical ability
2
68.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 18
VGNC:465
457028
Macaque
coiled-coil domain containing 18
713129
Mouse
MGI:1922974
73254
Rat
RGD:1564165
305628
Dog
coiled-coil domain containing 18
VGNC:38817
479946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 18
Macaque
coiled-coil domain containing 18
Mouse
Rat
Dog
coiled-coil domain containing 18
Publication Statistics
PubMed Score 1.40
PubMed score by year
PubTator Score 0.10
PubTator score by year
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Related Publications
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PMID
Year
Title