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Tbio
WLS
Protein wntless homolog

Protein Summary
Description
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262348
  • ENSP00000262348
  • ENSG00000116729
  • ENST00000354777
  • ENSP00000346829
  • ENST00000370976
  • ENSP00000360015

Symbol
  • C1orf139
  • GPR177
  • EVI
  • MRP
  • GPR177
  • mig-14
  • C1orf139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
trait
0.86
ligand (protein) perturbation
0.83
PubMedID
0.83
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.91   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.91   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
WNT7A
Tbio
Novelty:  0.00421662
p_int:  0.999902687
p_ni:  0.000097313
Score:  0.959
Data Source:  BioPlex,STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.98470409
p_ni:  0.01529591
Data Source:  BioPlex
WNT4
Tbio
Novelty:  0.00276803
p_int:  0.983537431
p_ni:  0.016462569
Score:  0.987
Data Source:  BioPlex,STRINGDB
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.980879718
p_ni:  0.019120282
Score:  0.153
Data Source:  BioPlex,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
p_int:  0.976955785
p_ni:  0.023044215
Score:  0.995
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.970736636
p_ni:  0.029263364
Data Source:  BioPlex
RPRM
Tbio
Novelty:  0.02938708
p_int:  0.941096543
p_ni:  0.058903458
Data Source:  BioPlex
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.925071026
p_ni:  0.074928975
Data Source:  BioPlex
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.892365179
p_ni:  0.107634821
Score:  0.175
Data Source:  BioPlex,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.883392931
p_ni:  0.116607069
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Signal Transduction (R-HSA-162582)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT ligand biogenesis and trafficking
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by WNT
WNT ligand biogenesis and trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
11
24
99.1
bone density
6
4
7
96.6
spine bone mineral density
2
1
2
75.5
femoral neck bone mineral density
1
1
1
72.3
hematocrit
2
2
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
24
99.1
bone density
7
96.6
spine bone mineral density
2
75.5
femoral neck bone mineral density
1
72.3
hematocrit
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
wntless Wnt ligand secretion mediator
VGNC:1636
456931
Macaque
wntless Wnt ligand secretion mediator
701411
Mouse
MGI:1915401
68151
Rat
RGD:735139
362065
Dog
wntless Wnt ligand secretion mediator
VGNC:48417
611491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
wntless Wnt ligand secretion mediator
Macaque
wntless Wnt ligand secretion mediator
Mouse
Rat
Dog
wntless Wnt ligand secretion mediator
Publication Statistics
PubMed Score 92.91
PubMed score by year
PubTator Score 96.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title