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Tbio
ATAD3B
ATPase family AAA domain-containing protein 3B

Protein Classes
Protein Summary
Description
May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308647
  • ENSP00000311766
  • ENSG00000160072

Symbol
  • KIAA1273
  • TOB3
  • TOB3
  • AAA-TOB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
virus perturbation
0.79
molecular function
0.73
histone modification site profile
0.7
protein domain
0.58


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Xenopus
ATPase family, AAA domain containing 3A
XB-GENE-946129
407895
Fruitfly
FBgn0040237
53565
Species
Name
OMA
EggNOG
Inparanoid
Xenopus
ATPase family, AAA domain containing 3A
Fruitfly
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T9A4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
NDUFAF1
Tclin
Novelty: 0.05630549
Score: 0.881
Data Source: STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
Score: 0.812
Data Source: STRINGDB
SRP68
Tbio
Novelty: 0.04666697
Score: 0.808
Data Source: STRINGDB
SSR1
Tbio
Novelty: 0.02009694
Score: 0.808
Data Source: STRINGDB
PHB2
Tbio
Novelty: 0.00458856
Score: 0.733
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.695
Data Source: STRINGDB
PHB
Tbio
Novelty: 0.00178383
Score: 0.685
Data Source: STRINGDB
POLG2
Tbio
Family: Enzyme
Novelty: 0.0233323
Score: 0.584
Data Source: STRINGDB
OXA1L
Tbio
Novelty: 0.00235517
Score: 0.58
Data Source: STRINGDB
SSBP1
Tbio
Novelty: 0.01105839
Score: 0.526
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.48

PubMed score by year
PubTator Score  7.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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