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Tbio
ACBD5
Acyl-CoA-binding domain-containing protein 5

Protein Summary
Description
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375888
  • ENSP00000365049
  • ENSG00000107897
  • ENST00000375901
  • ENSP00000365066
  • ENST00000375905
  • ENSP00000365070
  • ENST00000396271
  • ENSP00000379568

Symbol
  • KIAA1996
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.9
histone modification site profile
0.81
transcription factor perturbation
0.61
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999994
p_ni:  3e-9
p_wrong:  3e-9
Score:  0.782
Data Source:  BioPlex,STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.999999987
p_ni:  1e-9
p_wrong:  1.2e-8
Score:  0.272
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999981
p_ni:  1.8e-8
p_wrong:  1e-9
Score:  0.754
Data Source:  BioPlex,STRINGDB
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.999825521
p_ni:  0.000173764
p_wrong:  7.15e-7
Score:  0.547
Data Source:  BioPlex,STRINGDB
NECAB2
Tbio
Novelty:  0.16192956
p_int:  0.999823036
p_ni:  0.000176964
Score:  0.213
Data Source:  BioPlex,STRINGDB
ACBD7
Tdark
Novelty:  0.32019061
Score:  0.737
Data Source:  STRINGDB
HINT3
Tdark
Novelty:  1.14285714
Score:  0.676
Data Source:  STRINGDB
PEX19
Tbio
Novelty:  0.00605342
Score:  0.594
Data Source:  STRINGDB
SLC25A17
Tbio
Family:  Transporter
Novelty:  0.00601179
Score:  0.567
Data Source:  STRINGDB
ANKRD26
Tbio
Novelty:  0.02266046
Score:  0.561
Data Source:  STRINGDB
Pathways (6)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
1
2
73.7
platelet count
1
1
1
17.1
smoking initiation
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
73.7
platelet count
1
17.1
smoking initiation
1
4.1
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 5
VGNC:3794
450368
Macaque
acyl-CoA binding domain containing 5
708235
Mouse
MGI:1921409
74159
Dog
acyl-CoA binding domain containing 5
VGNC:37501
477987
Horse
acyl-CoA binding domain containing 5
VGNC:14973
100055334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 5
Macaque
acyl-CoA binding domain containing 5
Mouse
Dog
acyl-CoA binding domain containing 5
Horse
acyl-CoA binding domain containing 5
Publication Statistics
PubMed Score 13.14
PubMed score by year
PubTator Score 9.12
PubTator score by year