Protein Classes
Protein Summary
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000369547
- ENSP00000358560
- ENSG00000134207
- ENST00000607941
- ENSP00000476507
- ENST00000609117
- ENSP00000477344
- ENST00000610222
- ENSP00000476396
- sytVI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
microRNA | 0.84 | ||
cellular component | 0.71 | ||
molecular function | 0.7 | ||
cell line | 0.65 | ||
gene perturbation | 0.62 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.39 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 309 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.39 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 309 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (1)
PathwayCommons (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: panther | Synaptic_vesicle_trafficking | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Synaptic_vesicle_trafficking | ||||
Gene Ontology Terms (25)
Functions (8)
Components (10)
Processes (7)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (79)
1 – 10 of 79
SYT3
Novelty: 0.03816266
p_int: 0.999999999
p_ni: 1e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
SYT10
Novelty: 0.07565117
p_int: 0.999964911
p_ni: 9.7e-8
p_wrong: 0.000034992
Score: 0.9
Data Source: BioPlex,STRINGDB
AHCYL2
Family: Enzyme
Novelty: 0.10791598
p_int: 0.940172066
p_ni: 0.059827934
Data Source: BioPlex
MADD
Family: Enzyme
Novelty: 0.01721987
p_int: 0.937450516
p_ni: 0.062549484
Score: 0.822
Data Source: BioPlex,STRINGDB
SNAP25
Novelty: 0.0020914
Score: 0.775
Data Source: STRINGDB
STX3
Novelty: 0.01589793
Score: 0.699
Data Source: STRINGDB
VAMP2
Novelty: 0.00274235
Score: 0.672
Data Source: STRINGDB
SNAP23
Novelty: 0.00732279
Score: 0.671
Data Source: STRINGDB
STX1A
Novelty: 0.00128938
Score: 0.655
Data Source: STRINGDB
CPLX1
Novelty: 0.01111396
Score: 0.647
Data Source: STRINGDB
Publication Statistics
PubMed Score 13.39
PubMed score by year
PubTator Score 4.07
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSLLAVVVIVCGV
1-70
ALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLKDPSTLGFLEAAVKISHTSPD
70-140
IPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAEQPTSIGRIKPE
140-210
LYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCK
210-280
LQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWK
280-350
DIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK
350-420
KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPI
420-490
AHWHSLVEVKKSFKEGNPRL
490-510
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLKDPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPIAHWHSLVEVKKSFKEGNPRL
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