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Tbio
LCE1A
Late cornified envelope protein 1A

Protein Summary
Description
Precursors of the cornified envelope of the stratum corneum. LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335123
  • ENSP00000334869
  • ENSG00000186844

Symbol
  • LEP1
  • LEP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.63
virus perturbation
0.45
cell line
0.42
biological term
0.33
protein domain
0.26


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
LCE1B
Tbio
Novelty:  0.06933554
Score:  0.996
Data Source:  STRINGDB
LCE5A
Tdark
Novelty:  0.94159494
Score:  0.985
Data Source:  STRINGDB
LCE2B
Tdark
Novelty:  0.88335558
Score:  0.983
Data Source:  STRINGDB
LCE4A
Tdark
Novelty:  0.84149399
Score:  0.982
Data Source:  STRINGDB
LCE1D
Tbio
Novelty:  0.52901166
Score:  0.982
Data Source:  STRINGDB
LCE1F
Tdark
Novelty:  1.56312927
Score:  0.981
Data Source:  STRINGDB
LCE3C
Tbio
Novelty:  0.04910233
Score:  0.977
Data Source:  STRINGDB
LCE1E
Tdark
Novelty:  0.46343337
Score:  0.977
Data Source:  STRINGDB
LCE6A
Tdark
Novelty:  2.0416597
Score:  0.976
Data Source:  STRINGDB
LCE3B
Tbio
Novelty:  0.05400263
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
2
2
0
1.1
78.5
vitamin D measurement
1
2
2
51.2
1
1
0
1.2
43.6
1
1
0
1.2
37.4
vitamin D deficiency
1
1
1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
78.5
vitamin D measurement
2
51.2
0
1.2
43.6
0
1.2
37.4
vitamin D deficiency
1
21.1
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 28.91
PubMed score by year
PubTator Score 9.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title