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Tbio
KIF24
Kinesin-like protein KIF24

Protein Summary
Description
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They als ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379174
  • ENSP00000368472
  • ENSG00000186638
  • ENST00000402558
  • ENSP00000384433

Symbol
  • C9orf48
  • C9orf48
  • bA571F15.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
histone modification site profile
0.82
tissue sample
0.7
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
56.2
diet measurement
1
1
1
53.3
adolescent idiopathic scoliosis
1
1
0
1.7
33.1
plasminogen activator inhibitor 1 measurement
1
1
0
430.4
17.8
creatine kinase measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
56.2
diet measurement
1
53.3
adolescent idiopathic scoliosis
0
1.7
33.1
plasminogen activator inhibitor 1 measurement
0
430.4
17.8
creatine kinase measurement
1
17.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918345
109242
Rat
RGD:1307723
313170
Dog
kinesin family member 24
VGNC:42399
481585
Horse
kinesin family member 24
VGNC:19410
100068535
Cow
kinesin family member 24
VGNC:30597
513392
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
kinesin family member 24
Horse
kinesin family member 24
Cow
kinesin family member 24
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T7B8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
CCP110
Tbio
Novelty:  0.02399511
Score:  0.987
Data Source:  STRINGDB
CEP97
Tbio
Novelty:  0.12709162
Score:  0.981
Data Source:  STRINGDB
NEK2
Tchem
Family:  Kinase
Novelty:  0.0059613
Score:  0.979
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.959
Data Source:  STRINGDB
CEP83
Tdark
Novelty:  0.15704554
Score:  0.958
Data Source:  STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
Score:  0.958
Data Source:  STRINGDB
CEP76
Tdark
Novelty:  0.3880387
Score:  0.957
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.957
Data Source:  STRINGDB
TTBK2
Tbio
Family:  Kinase
Novelty:  0.03262289
Score:  0.957
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.63

PubMed score by year
PubTator Score  4.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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