Tbio GPRC6A G-protein coupled receptor family C group 6 member A

Protein Summary

Description

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q5T6X5
• Q6JK43
• Q6JK44
• Q8NGU8
• Q8NHZ9
• Q8TDT6
• hGPRC6A

Gene Name

• GPRC6A

Ensembl ID

• ENST00000310357
• ENSP00000309493
• ENSG00000173612
• ENST00000368549
• ENSP00000357537
• ENST00000530250
• ENSP00000433465

Symbol

• GPCR
• bA86F4.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cell type or tissue	0.73
tissue	0.51
ligand (chemical)	0.49
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Ionotropic Glutamate Receptor / G-protein Coupled Receptor Family C Group 6 Member A

Protein / Receptor / Ligand-gated Ion Channel / Ionotropic Glutamate Receptor / G-protein Coupled Receptor Family C Group 6 Member A

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor Family C Group 6 Member A

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Calcium-sensing Receptor / G-protein Coupled Receptor Family C Group 6 Member A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.3   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.3   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1