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Tchem
GPRC6A
G-protein coupled receptor family C group 6 member A

Protein Classes
Protein Summary
Description
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310357
  • ENSP00000309493
  • ENSG00000173612
  • ENST00000368549
  • ENSP00000357537
  • ENST00000530250
  • ENSP00000433465

Symbol
  • GPCR
  • bA86F4.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.73
tissue
0.51
ligand (chemical)
0.49
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.2   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.2   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
31.2
parental genotype effect measurement
1
1
1
1
birth weight
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
31.2
parental genotype effect measurement
1
1
birth weight
1
1
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (203)
1 – 10 of 203
FFAR2
Tchem
Family: GPCR
Novelty: 0.00361123
Score: 0.97
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.958
Data Source: STRINGDB
FFAR1
Tchem
Family: GPCR
Novelty: 0.00271782
Score: 0.957
Data Source: STRINGDB
FFAR3
Tchem
Family: GPCR
Novelty: 0.00746169
Score: 0.956
Data Source: STRINGDB
FFAR4
Tchem
Family: GPCR
Novelty: 0.00439747
Score: 0.948
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.944
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.94
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.93
Data Source: STRINGDB
GAST
Tbio
Novelty: 0.00011795
Score: 0.93
Data Source: STRINGDB
NPSR1
Tchem
Family: GPCR
Novelty: 0.00562139
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.20

PubMed score by year
PubTator Score  36.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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