You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ERMARD
Endoplasmic reticulum membrane-associated RNA degradation protein

Protein Summary
Description
May play a role in neuronal migration during embryonic development. The protein encoded by this gene contains 2 transmembrane domains near the C-terminus and is localized in the endoplasmic reticulum. Knockout of this gene in developing rat brain showed that it may be involved in neuronal migration. Mutations in this gene are associated with periventricular nodular heterotopia-6 (PVNH6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366772
  • ENSP00000355734
  • ENSG00000130023
  • ENST00000366773
  • ENSP00000355735
  • ENST00000392095
  • ENSP00000375945
  • ENST00000418781
  • ENSP00000397661
  • ENST00000611694
  • ENSP00000483849
  • ENSG00000276187
  • ENST00000615090
  • ENSP00000480327
  • ENST00000616801
  • ENSP00000483960
  • ENST00000621205
  • ENSP00000483666

Symbol
  • C6orf70
  • PVNH6
  • C6orf70
  • dJ266L20.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.82
transcription factor binding site profile
0.66
tissue sample
0.59
transcription factor
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0