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Tdark
ERMARD
Endoplasmic reticulum membrane-associated RNA degradation protein

Protein Summary
Description
May play a role in neuronal migration during embryonic development. The protein encoded by this gene contains 2 transmembrane domains near the C-terminus and is localized in the endoplasmic reticulum. Knockout of this gene in developing rat brain showed that it may be involved in neuronal migration. Mutations in this gene are associated with periventricular nodular heterotopia-6 (PVNH6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366772
  • ENSP00000355734
  • ENSG00000130023
  • ENST00000366773
  • ENSP00000355735
  • ENST00000392095
  • ENSP00000375945
  • ENST00000418781
  • ENSP00000397661
  • ENST00000611694
  • ENSP00000483849
  • ENSG00000276187
  • ENST00000615090
  • ENSP00000480327
  • ENST00000616801
  • ENSP00000483960
  • ENST00000621205
  • ENSP00000483666

Symbol
  • C6orf70
  • PVNH6
  • C6orf70
  • dJ266L20.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.82
transcription factor binding site profile
0.66
tissue sample
0.59
transcription factor
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
44.2
self reported educational attainment
1
1
1
44.2
smoking status measurement
1
1
1
24.5
smoking status measurement
1
1
1
24.5
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
44.2
self reported educational attainment
1
44.2
smoking status measurement
1
24.5
smoking status measurement
1
24.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane associated RNA degradation
VGNC:11070
463142
Mouse
MGI:1917317
381062
Dog
ER membrane associated RNA degradation
VGNC:40461
475039
Horse
ER membrane associated RNA degradation
VGNC:17671
100053169
Cow
ER membrane associated RNA degradation
VGNC:28590
512804
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane associated RNA degradation
Mouse
Dog
ER membrane associated RNA degradation
Horse
ER membrane associated RNA degradation
Cow
ER membrane associated RNA degradation
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T6L9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
ARFGEF2
Tbio
Novelty:  0.05568966
Score:  0.809
Data Source:  STRINGDB
CFAP46
Tdark
Novelty:  0.73818628
Score:  0.747
Data Source:  STRINGDB
TCP10L2
Tdark
Novelty:  4.42416561
Score:  0.69
Data Source:  STRINGDB
TCP10
Tbio
Novelty:  0.06680788
Score:  0.682
Data Source:  STRINGDB
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
Score:  0.68
Data Source:  STRINGDB
CHST15
Tbio
Family:  Enzyme
Novelty:  0.03950241
Score:  0.651
Data Source:  STRINGDB
FAM120B
Tbio
Novelty:  0.07982799
Score:  0.585
Data Source:  STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
Score:  0.555
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.555
Data Source:  STRINGDB
C6orf118
Tdark
Novelty:  4.32054176
Score:  0.537
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.01

PubMed score by year
PubTator Score  3.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer