Tbio DCAF12 DDB1- and CUL4-associated factor 12

Protein Summary

Description

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q5T6F0
• A8KA70
• D3DRL6
• Q5T6E9
• Q5T6F1
• Q6P3V0
• Q7L4F8
• Q96PZ5
• Q9NXA9
• Q9UFJ1

Gene Name

• DCAF12

Ensembl ID

• ENST00000361264
• ENSP00000355114
• ENSG00000198876

Symbol

• KIAA1892
• TCC52
• WDR40A
• CT102
• TCC52
• WDR40A
• KIAA1892

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
microRNA	0.74
transcription factor binding site profile	0.71
cell type or tissue	0.67
gene perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0