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Tbio
CAMSAP1
Calmodulin-regulated spectrin-associated protein 1

Protein Summary
Description
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312405
  • ENSP00000312463
  • ENSG00000130559
  • ENST00000389532
  • ENSP00000374183
  • ENST00000409386
  • ENSP00000386420
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
disease perturbation
0.79
microRNA
0.78
virus perturbation
0.76
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.35   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.35   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
TUBA1A
Tchem
Novelty: 0.01030145
Score: 0.945
Data Source: STRINGDB
UBAC1
Tbio
Novelty: 0.00122518
Score: 0.801
Data Source: STRINGDB
SURF6
Tbio
Novelty: 0.0507355
Score: 0.75
Data Source: STRINGDB
TUBA1B
Tchem
Novelty: 0.02465964
Score: 0.739
Data Source: STRINGDB
TUBA3D
Tdark
Novelty: 0.01931631
Score: 0.736
Data Source: STRINGDB
TUBA1C
Tchem
Novelty: 0.02804632
Score: 0.736
Data Source: STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
Score: 0.736
Data Source: STRINGDB
TUBA3E
Tchem
Novelty: 1.70475533
Score: 0.736
Data Source: STRINGDB
AK8
Tbio
Family: Kinase
Novelty: 0.05983262
Score: 0.735
Data Source: STRINGDB
FAM69B
Tdark
Novelty: 0.98107345
Score: 0.71
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.35

PubMed score by year
PubTator Score  2.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer