Tbio BEND3 BEN domain-containing protein 3

Protein Summary

Description

Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671).

Uniprot Accession IDs

• Q5T5X7
• A2RRH2
• Q9HCL9

Gene Name

• BEND3

Ensembl ID

• ENST00000369042
• ENSP00000358038
• ENSG00000178409
• ENST00000429433
• ENSP00000411268

Symbol

• KIAA1553
• KIAA1553

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.67
transcription factor binding site profile	0.59
microRNA	0.57
histone modification site profile	0.52
protein complex	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0