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Tbio
ARHGAP21
Rho GTPase-activating protein 21

Protein Summary
Description
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320481
  • ENSP00000365604
  • ENSG00000107863
  • ENST00000396432
  • ENSP00000379709

Symbol
  • ARHGAP10
  • KIAA1424
  • ARHGAP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
cellular component
0.78
protein domain
0.73
virus perturbation
0.72
cell line
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.25   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.25   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
29.3
atrophic macular degeneration
1
1
0
1.1
29.3
1
1
0
1.1
29.3
reticulocyte measurement
1
1
1
22.3
appendicular lean mass
1
1
1
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
29.3
atrophic macular degeneration
0
1.1
29.3
0
1.1
29.3
reticulocyte measurement
1
22.3
appendicular lean mass
1
18.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918685
71435
Rat
RGD:1311028
307178
Dog
Rho GTPase activating protein 21
VGNC:38051
100687590
Horse
Rho GTPase activating protein 21
VGNC:15463
100066007
Cow
Rho GTPase activating protein 21
VGNC:26080
538584
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Rho GTPase activating protein 21
Horse
Rho GTPase activating protein 21
Cow
Rho GTPase activating protein 21
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5T5U3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (57)
1 – 10 of 57
SAPCD1
Tdark
Novelty: 0.90892824
p_int: 0.999999981
p_ni: 1.9e-8
Score: 0.485
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999743231
p_ni: 0.000251902
p_wrong: 0.000004867
Data Source: BioPlex
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.973
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.963
Data Source: STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.952
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.928
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.925
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.925
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.919
Data Source: STRINGDB
RHOH
Tbio
Family: Enzyme
Novelty: 0.00882842
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.25

PubMed score by year
PubTator Score  7.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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