Tbio ARHGAP21 Rho GTPase-activating protein 21

Protein Summary

Description

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5T5U3
• Q0VF98
• Q7Z3P7
• Q8N3A2
• Q8NI19
• Q8TBV5
• Q9P2C3

Gene Name

• ARHGAP21

Ensembl ID

• ENST00000320481
• ENSP00000365604
• ENSG00000107863
• ENST00000396432
• ENSP00000379709

Symbol

• ARHGAP10
• KIAA1424
• ARHGAP10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.8
cellular component	0.78
protein domain	0.73
virus perturbation	0.72
cell line	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.81   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.81   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0