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Tbio
ARTN
Artemin

Protein Summary
Description
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of per ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372354
  • ENSP00000361429
  • ENSG00000117407
  • ENST00000372359
  • ENSP00000361434
  • ENST00000414809
  • ENSP00000387435
  • ENST00000438616
  • ENSP00000391998
  • ENST00000498139
  • ENSP00000436727

Symbol
  • EVN
  • ART
  • EVN
  • NBN
  • ENOVIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
small molecule perturbation
0.69
gene perturbation
0.67
transcription factor
0.63
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.11   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.11   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
1 – 10 of 67
GFRA3
Tbio
Novelty:  0.10149548
Score:  0.988
Data Source:  Reactome,STRINGDB
GFRA4
Tbio
Novelty:  0.17473076
Score:  0.975
Data Source:  Reactome,STRINGDB
GFRA1
Tbio
Novelty:  0.00373994
Score:  0.972
Data Source:  Reactome,STRINGDB
RET
Tclin
Family:  Kinase
Novelty:  0.00028324
Score:  0.969
Data Source:  Reactome,STRINGDB
GFRA2
Tbio
Novelty:  0.06235436
Score:  0.945
Data Source:  Reactome,STRINGDB
FRS2
Tbio
Novelty:  0.00654052
Score:  0.937
Data Source:  Reactome,STRINGDB
GDNF
Tbio
Novelty:  0.00036702
Score:  0.928
Data Source:  Reactome,STRINGDB
NRTN
Tbio
Novelty:  0.00547984
Score:  0.923
Data Source:  Reactome,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.916
Data Source:  Reactome,STRINGDB
PSPN
Tbio
Novelty:  0.02169895
Score:  0.916
Data Source:  Reactome,STRINGDB
Pathways (14)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
6
80.5
intelligence
4
4
2
6
76.1
cognitive function measurement
3
2
3
66.3
household income
1
2
2
60.8
age at first sexual intercourse measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
80.5
intelligence
2
6
76.1
cognitive function measurement
3
66.3
household income
2
60.8
age at first sexual intercourse measurement
1
52
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
artemin
VGNC:445
469310
Macaque
artemin
701641
Mouse
MGI:1333791
11876
Rat
RGD:621427
362572
Cow
artemin
VGNC:26181
530812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
artemin
Macaque
artemin
Mouse
Rat
Cow
artemin
Publication Statistics
PubMed Score 139.11
PubMed score by year
PubTator Score 187.40
PubTator score by year