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Tbio
UBR4
E3 ubiquitin-protein ligase UBR4

Protein Summary
Description
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 201 ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
interacting protein
0.9
virus
0.89
histone modification site profile
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
77.7
viral load
1
1
1
68.6
Thyroid preparation use measurement
1
1
1
26.1
plasminogen activator inhibitor 1 measurement
1
1
0
634.6
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
77.7
viral load
1
68.6
Thyroid preparation use measurement
1
26.1
plasminogen activator inhibitor 1 measurement
0
634.6
12.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 4
VGNC:9408
456576
Macaque
ubiquitin protein ligase E3 component n-recognin 4
702449
Mouse
MGI:1916366
69116
Rat
RGD:1563121
313658
Dog
ubiquitin protein ligase E3 component n-recognin 4
VGNC:48091
478211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 4
Macaque
ubiquitin protein ligase E3 component n-recognin 4
Mouse
Rat
Dog
ubiquitin protein ligase E3 component n-recognin 4
Protein Structure (0 Structures, 20 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Innate Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (487)
1 – 10 of 487
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.999951708
p_ni:  0.000048292
Score:  0.952
Data Source:  BioPlex,STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
p_int:  0.986163988
p_ni:  0.013836012
Score:  0.512
Data Source:  BioPlex,STRINGDB
TFDP3
Tbio
Family:  TF
Novelty:  0.00223003
p_int:  0.985648817
p_ni:  0.014351183
Score:  0.221
Data Source:  BioPlex,STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.970803368
p_ni:  0.029196632
Score:  0.533
Data Source:  BioPlex,STRINGDB
METTL2A
Tdark
Family:  Enzyme
Novelty:  0.72443397
p_int:  0.968435265
p_ni:  0.031564735
Data Source:  BioPlex
VEGFD
Tbio
Novelty:  0.00233128
p_int:  0.966958496
p_ni:  0.033041504
Score:  0.638
Data Source:  BioPlex,STRINGDB
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.961923768
p_ni:  0.038076232
Data Source:  BioPlex
FSTL4
Tdark
Novelty:  0.29038823
p_int:  0.958075759
p_ni:  0.041924241
Score:  0.795
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.957706715
p_ni:  0.042293285
Data Source:  BioPlex
LYPD6B
Tdark
Novelty:  0.1409054
p_int:  0.95405394
p_ni:  0.04594606
Data Source:  BioPlex
Publication Statistics
PubMed Score  28.82

PubMed score by year
PubTator Score  10.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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