Tbio UBR4 E3 ubiquitin-protein ligase UBR4

Protein Summary

Description

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q5T4S7
• A8MPT2
• A8MQ33
• A8MQB1
• O60646
• O75050
• Q4QRK5
• Q5T4S8
• Q5T4S9
• Q5TBN8
• Q5TBP2
• Q6DKH8
• Q6P4A4
• Q7L8P7
• Q8IXJ4
• Q8TDN5
• Q8WV67
• Q9HA46
• Q9P2N9
• Q9UG82

Gene Name

• UBR4

Ensembl ID

• ENST00000375218
• ENSP00000364366
• ENSG00000127481
• ENST00000375254
• ENSP00000364403

Symbol

• KIAA0462
• KIAA1307
• RBAF600
• ZUBR1
• p600
• ZUBR1
• RBAF600

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
interacting protein	0.9
virus	0.89
histone modification site profile	0.85
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.26   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.26   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0