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Tbio
SFRP5
Secreted frizzled-related protein 5

Protein Summary
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266066
  • ENSP00000266066
  • ENSG00000120057

Symbol
  • FRP1B
  • SARP3
  • SARP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
protein domain
0.73
PubMedID
0.66
cell type or tissue
0.62
tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.89   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.89   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-linolenic acid measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-linolenic acid measurement
1
0.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1860298
54612
Rat
RGD:1310369
309377
Dog
secreted frizzled related protein 5
VGNC:46083
486826
Cow
secreted frizzled related protein 5
VGNC:34523
282069
Pig
secreted frizzled related protein 5
100153176
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
secreted frizzled related protein 5
Cow
secreted frizzled related protein 5
Pig
secreted frizzled related protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T4F7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (74)
1 – 10 of 74
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.944
Data Source:  STRINGDB
WNT8B
Tbio
Novelty:  0.0140304
Score:  0.943
Data Source:  STRINGDB
WNT8A
Tbio
Novelty:  0.01404009
Score:  0.932
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.923
Data Source:  STRINGDB
WNT7A
Tbio
Novelty:  0.00421662
Score:  0.907
Data Source:  STRINGDB
WNT9B
Tbio
Novelty:  0.01146843
Score:  0.907
Data Source:  STRINGDB
WNT5B
Tbio
Novelty:  0.00919779
Score:  0.902
Data Source:  STRINGDB
WNT2B
Tbio
Novelty:  0.00783711
Score:  0.899
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.898
Data Source:  STRINGDB
WNT10A
Tbio
Novelty:  0.00641352
Score:  0.896
Data Source:  STRINGDB
Publication Statistics
PubMed Score  130.89

PubMed score by year
PubTator Score  75.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer