Tbio ZFYVE27 Protrudin

Protein Summary

Description

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q5T4F4
• B7Z3S0
• B7Z404
• B7Z626
• G8JLC3
• G8JLF0
• J3KP98
• Q5T4F1
• Q5T4F2
• Q5T4F3
• Q8N1K0
• Q8N6D6
• Q8NCA0
• Q8NDE4
• Q96M08

Gene Name

• ZFYVE27

Ensembl ID

• ENST00000337540
• ENSP00000337993
• ENSG00000155256
• ENST00000357540
• ENSP00000350148
• ENST00000359980
• ENSP00000353069
• ENST00000370610
• ENSP00000359642
• ENST00000370613
• ENSP00000359646
• ENST00000393677
• ENSP00000377282
• ENST00000423811
• ENSP00000409594

Symbol

• SPG33
• SPG33
• PROTRUDIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.8
histone modification site profile	0.78
cell type or tissue	0.76
cellular component	0.75
transcription factor binding site profile	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0