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Tdark
HECTD3
E3 ubiquitin-protein ligase HECTD3

Protein Summary
Description
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372168
  • ENSP00000361241
  • ENSG00000126107
  • ENST00000372172
  • ENSP00000361245
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
cell type or tissue
0.66
interacting protein
0.66
protein complex
0.65
transcription factor binding site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
15.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT domain E3 ubiquitin protein ligase 3
VGNC:1257
456542
Macaque
HECT domain E3 ubiquitin protein ligase 3
705051
Mouse
MGI:1923858
76608
Dog
HECT domain E3 ubiquitin protein ligase 3
VGNC:54210
482518
Horse
HECT domain E3 ubiquitin protein ligase 3
VGNC:18737
100065625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT domain E3 ubiquitin protein ligase 3
Macaque
HECT domain E3 ubiquitin protein ligase 3
Mouse
Dog
HECT domain E3 ubiquitin protein ligase 3
Horse
HECT domain E3 ubiquitin protein ligase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T447-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (327)
1 – 10 of 327
RPS4X
Tbio
Novelty:  0.01396038
p_int:  0.999552893
p_ni:  0.000447107
Score:  0.241
Data Source:  BioPlex,STRINGDB
GREM2
Tbio
Novelty:  0.01839564
p_int:  0.999279795
p_ni:  0.000720205
Data Source:  BioPlex
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.998788694
p_ni:  0.001211306
Data Source:  BioPlex
CCDC130
Tdark
Novelty:  0.34042834
p_int:  0.998173913
p_ni:  0.001826087
Score:  0.159
Data Source:  BioPlex,STRINGDB
CHRDL1
Tbio
Novelty:  0.01748654
p_int:  0.997496223
p_ni:  0.002503777
Score:  0.183
Data Source:  BioPlex,STRINGDB
EGFL6
Tbio
Novelty:  0.04347552
p_int:  0.995911002
p_ni:  0.004088998
Score:  0.172
Data Source:  BioPlex,STRINGDB
WNT9B
Tbio
Novelty:  0.01146843
p_int:  0.99553969
p_ni:  0.00446031
Score:  0.204
Data Source:  BioPlex,STRINGDB
ANGPT2
Tbio
Novelty:  0.00116183
p_int:  0.991707186
p_ni:  0.008292814
Score:  0.189
Data Source:  BioPlex,STRINGDB
RBFA
Tbio
Novelty:  0.1061138
p_int:  0.991553086
p_ni:  0.008446914
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.991089373
p_ni:  0.008910627
Score:  0.167
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.26

PubMed score by year
PubTator Score  3.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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