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Tbio
ABCC10
Multidrug resistance-associated protein 7

Protein Summary
Description
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244533
  • ENSP00000244533
  • ENSG00000124574
  • ENST00000372530
  • ENSP00000361608

Symbol
  • MRP7
  • SIMRP7
  • MRP7
  • SIMRP7
  • EST182763
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
molecular function
0.98
protein domain
0.85
transcription factor perturbation
0.8
histone modification site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.87   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.87   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
84.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 10
VGNC:11026
462717
Mouse
MGI:2386976
224814
Rat
RGD:1306696
316231
Dog
ATP binding cassette subfamily C member 10
VGNC:37437
481813
Horse
ATP binding cassette subfamily C member 10
VGNC:14914
100067430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 10
Mouse
Rat
Dog
ATP binding cassette subfamily C member 10
Horse
ATP binding cassette subfamily C member 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T3U5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Transport of small molecules
Protein-Protein Interactions (30)
1 – 10 of 30
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.999106704
p_ni: 0.000893107
p_wrong: 1.88e-7
Data Source: BioPlex
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.997532798
p_ni: 0.002467202
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.996801953
p_ni: 0.003173292
p_wrong: 0.000024755
Score: 0.157
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.996748668
p_ni: 0.003201758
p_wrong: 0.000049573
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.988982981
p_ni: 0.010857212
p_wrong: 0.000159806
Score: 0.178
Data Source: BioPlex,STRINGDB
CHRND
Tclin
Family: IC
Novelty: 0.0441685
p_int: 0.986097661
p_ni: 0.013747526
p_wrong: 0.000154814
Score: 0.197
Data Source: BioPlex,STRINGDB
TEX264
Tdark
Novelty: 0.32406417
p_int: 0.974809458
p_ni: 0.023764129
p_wrong: 0.001426413
Score: 0.183
Data Source: BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty: 0.28397695
p_int: 0.953846176
p_ni: 0.03507356
p_wrong: 0.011080264
Data Source: BioPlex
CHRM4
Tclin
Family: GPCR
Novelty: 0.00759817
p_int: 0.952945548
p_ni: 0.046986192
p_wrong: 0.000068261
Data Source: BioPlex
SV2C
Tbio
Novelty: 0.03221681
p_int: 0.942898818
p_ni: 0.048280844
p_wrong: 0.008820337
Score: 0.251
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.87

PubMed score by year
PubTator Score  48.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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