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Tdark
TMEM63B
CSC1-like protein 2

Protein Summary
Description
Acts as an osmosensitive calcium-permeable cation channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259746
  • ENSP00000259746
  • ENSG00000137216
  • ENST00000323267
  • ENSP00000327154

Symbol
  • C6orf110
  • C6orf110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.71
transcription factor perturbation
0.61
histone modification site profile
0.6
cell type or tissue
0.58
transcription factor binding site profile
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (68)
1 – 10 of 68
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999490649
p_ni:  0.00050935
p_wrong:  1e-9
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.998404596
p_ni:  0.001595326
p_wrong:  7.9e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.996329925
p_ni:  0.003669216
p_wrong:  8.59e-7
Data Source:  BioPlex
PCDHA3
Tdark
Novelty:  0.8622898
p_int:  0.996288582
p_ni:  0.003711219
p_wrong:  2e-7
Data Source:  BioPlex
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.996219971
p_ni:  0.003779971
p_wrong:  5.9e-8
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.995626525
p_ni:  0.004373288
p_wrong:  1.87e-7
Data Source:  BioPlex
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.994571762
p_ni:  0.005428234
p_wrong:  4e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.983313403
p_ni:  0.016413923
p_wrong:  0.000272673
Data Source:  BioPlex
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.983183334
p_ni:  0.016816638
p_wrong:  2.7e-8
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.980637388
p_ni:  0.019362598
p_wrong:  1.4e-8
Data Source:  BioPlex
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
2
2
2
89.2
hematocrit
5
1
5
87.3
hemoglobin measurement
4
1
4
87
red blood cell density measurement
2
1
2
86.7
mean reticulocyte volume
1
2
2
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
2
89.2
hematocrit
5
87.3
hemoglobin measurement
4
87
red blood cell density measurement
2
86.7
mean reticulocyte volume
2
85
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63B
VGNC:3754
472016
Macaque
transmembrane protein 63B
702797
Mouse
MGI:2387609
224807
Rat
RGD:1305862
363197
Dog
transmembrane protein 63B
VGNC:47596
609620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63B
Macaque
transmembrane protein 63B
Mouse
Rat
Dog
transmembrane protein 63B
Publication Statistics
PubMed Score 4.23
PubMed score by year
PubTator Score 0.33
PubTator score by year