You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PDZK1
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Protein Summary
Description
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344770
  • ENSP00000342143
  • ENSG00000174827
  • ENST00000417171
  • ENSP00000394485
  • ENST00000451928
  • ENSP00000403422

Symbol
  • CAP70
  • NHERF3
  • PDZD1
  • CAP70
  • CLAMP
  • PDZD1
  • NHERF3
  • NHERF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.92
small molecule perturbation
0.67
transcription factor
0.63
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
3
6
3.3
98.5
uric acid measurement
4
3
6
95.5
contrast sensitivity measurement
1
1
0
5.7
34.2
overweight body mass index status
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
3.3
98.5
uric acid measurement
6
95.5
contrast sensitivity measurement
0
5.7
34.2
overweight body mass index status
1
2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 1
VGNC:11606
100611671
Macaque
PDZ domain containing 1
696698
Mouse
MGI:1928901
59020
Rat
RGD:70924
65144
Dog
PDZ domain containing 1
475823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 1
Macaque
PDZ domain containing 1
Mouse
Rat
Dog
PDZ domain containing 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5T2W1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (94)
1 – 10 of 94
ABCC2
Tchem
Family: Transporter
Novelty: 0.00110828
Score: 0.936
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.932
Data Source: STRINGDB
SCARB1
Tchem
Novelty: 0.00087703
Score: 0.897
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.891
Data Source: STRINGDB
SLC22A12
Tclin
Family: Transporter
Novelty: 0.00318081
Score: 0.888
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.876
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.838
Data Source: STRINGDB
KIRREL2
Tbio
Novelty: 0.0349023
Score: 0.804
Data Source: STRINGDB
KCTD5
Tbio
Novelty: 0.07740057
Score: 0.8
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01343595
Score: 0.773
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.16

PubMed score by year
PubTator Score  60.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: