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Tbio
PDSS1
Decaprenyl-diphosphate synthase subunit 1

Protein Summary
Description
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376215
  • ENSP00000365388
  • ENSG00000148459

Symbol
  • DPS1
  • TPRT
  • DPS
  • SPS
  • TPT
  • COQ1
  • TPRT
  • COQ1A
  • TPT 1
  • hDPS1
  • COQ10D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor
0.84
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.17   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.17   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999998495
p_ni:  0.00000133
p_wrong:  1.75e-7
Data Source:  BioPlex
NECTIN4
Tclin
Novelty:  0.00694563
p_int:  0.999995159
p_ni:  0.000004825
p_wrong:  1.6e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
p_int:  0.999986208
p_ni:  0.000013767
p_wrong:  2.5e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.999947956
p_ni:  0.000003933
p_wrong:  0.000048111
Score:  0.831
Data Source:  BioPlex,STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
p_int:  0.99989696
p_ni:  0.000043607
p_wrong:  0.000059433
Score:  0.772
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999282543
p_ni:  0.0003289
p_wrong:  0.000388557
Data Source:  BioPlex
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.954849519
p_ni:  0.00040228
p_wrong:  0.0447482
Score:  0.977
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.775866831
p_ni:  0.001591143
p_wrong:  0.222542025
Data Source:  BioPlex
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.995
Data Source:  STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
Score:  0.971
Data Source:  STRINGDB
Pathways (8)
Metabolism (R-HSA-1430728)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
decaprenyl diphosphate synthase subunit 1
VGNC:14564
450362
Macaque
decaprenyl diphosphate synthase subunit 1
707598
Mouse
MGI:1889278
56075
Rat
RGD:2319976
100364990
Dog
decaprenyl diphosphate synthase subunit 1
VGNC:44394
607944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
decaprenyl diphosphate synthase subunit 1
Macaque
decaprenyl diphosphate synthase subunit 1
Mouse
Rat
Dog
decaprenyl diphosphate synthase subunit 1
Publication Statistics
PubMed Score 61.17
PubMed score by year
PubTator Score 43.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title