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Tbio
TREML2
Trem-like transcript 2 protein

Protein Summary
Description
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000483722
  • ENSP00000418767
  • ENSG00000112195

Symbol
  • C6orf76
  • TLT2
  • TLT2
  • TLT-2
  • C6orf76
  • dJ238O23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
protein domain
0.58
microRNA
0.55
cell line
0.5
transcription factor
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
87.7
late-onset Alzheimers disease
1
2
0
2.1
87.7
2
2
0
4.2
66.6
leukocyte count
1
1
1
64.4
mean corpuscular volume
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
87.7
late-onset Alzheimers disease
0
2.1
87.7
0
4.2
66.6
leukocyte count
1
64.4
mean corpuscular volume
1
58.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 2
VGNC:3771
748479
Macaque
triggering receptor expressed on myeloid cells like 2
719749
Mouse
MGI:2147038
328833
Rat
RGD:1587039
680844
Dog
triggering receptor expressed on myeloid cells like 2
VGNC:47795
481791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 2
Macaque
triggering receptor expressed on myeloid cells like 2
Mouse
Rat
Dog
triggering receptor expressed on myeloid cells like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T2D2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (23)
1 – 10 of 23
ZBTB1
Tbio
Family:  TF
Novelty:  0.33667235
p_int:  0.999600423
p_ni:  0.000386571
p_wrong:  0.000013006
Score:  0.228
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.999519422
p_ni:  0.000480578
Score:  0.183
Data Source:  BioPlex,STRINGDB
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.997102211
p_ni:  0.00289704
p_wrong:  7.49e-7
Score:  0.174
Data Source:  BioPlex,STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
p_int:  0.984727973
p_ni:  0.015268485
p_wrong:  0.000003542
Score:  0.228
Data Source:  BioPlex,STRINGDB
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.930411949
p_ni:  0.069588051
Score:  0.158
Data Source:  BioPlex,STRINGDB
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.928965889
p_ni:  0.071034111
Score:  0.183
Data Source:  BioPlex,STRINGDB
DHRS7
Tbio
Family:  Enzyme
Novelty:  0.16713756
p_int:  0.878104551
p_ni:  0.121895449
Score:  0.181
Data Source:  BioPlex,STRINGDB
TREML1
Tbio
Novelty:  0.03513416
Score:  0.913
Data Source:  STRINGDB
TREM1
Tbio
Novelty:  0.00249253
Score:  0.901
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.757
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.95

PubMed score by year
PubTator Score  9.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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