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Tbio
UTF1
Undifferentiated embryonic cell transcription factor 1

Protein Summary
Description
Acts as a transcriptional coactivator of ATF2. The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304477
  • ENSP00000305906
  • ENSG00000171794
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.68
PubMedID
0.67
gene perturbation
0.65
cell type or tissue
0.63
biological process
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.84691686
p_ni:  7e-9
p_wrong:  0.153083134
Score:  0.282
Data Source:  BioPlex,STRINGDB
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.851
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.756
Data Source:  STRINGDB
ESRRB
Tchem
Family:  NR
Novelty:  0.00620739
Score:  0.731
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.724
Data Source:  STRINGDB
SALL4
Tbio
Family:  TF
Novelty:  0.00354374
Score:  0.709
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.7
Data Source:  STRINGDB
FGF4
Tbio
Novelty:  0.00180667
Score:  0.699
Data Source:  STRINGDB
LIN28A
Tbio
Family:  TF
Novelty:  0.00199524
Score:  0.698
Data Source:  STRINGDB
ZFP42
Tbio
Family:  TF
Novelty:  0.03022542
Score:  0.693
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
28.1
multisite chronic pain
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
28.1
multisite chronic pain
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1276125
22286
Rat
RGD:1589375
681901
Cow
undifferentiated embryonic cell transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12634]
Pig
undifferentiated embryonic cell transcription factor 1
100158138
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
undifferentiated embryonic cell transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12634]
Pig
undifferentiated embryonic cell transcription factor 1
Publication Statistics
PubMed Score 52.99
PubMed score by year
PubTator Score 32.31
PubTator score by year
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Related Publications
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PMID
Year
Title