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Tbio
THEM4
Acyl-coenzyme A thioesterase THEM4

Protein Summary
Description
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368814
  • ENSP00000357804
  • ENSG00000159445

Symbol
  • CTMP
  • CTMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.82
histone modification site profile
0.78
disease
0.67
pathway
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.62   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.62   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
THEM5
Tbio
Family:  Enzyme
Novelty:  0.20267249
p_int:  0.99999994
p_ni:  6e-8
Data Source:  BioPlex
GSTT2
Tdark
Family:  Enzyme
p_int:  0.999999779
p_ni:  1e-9
p_wrong:  2.2e-7
Data Source:  BioPlex
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
p_int:  0.999986208
p_ni:  0.000013767
p_wrong:  2.5e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.99996952
p_ni:  0.00003048
Score:  0.186
Data Source:  BioPlex,STRINGDB
PDSS2
Tbio
Family:  Enzyme
Novelty:  0.02716477
p_int:  0.999963465
p_ni:  0.000002259
p_wrong:  0.000034276
Score:  0.188
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.999886375
p_ni:  0.000113625
p_wrong:  1e-9
Data Source:  BioPlex
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
p_int:  0.999215802
p_ni:  0.000784198
Score:  0.679
Data Source:  BioPlex,STRINGDB
FPGS
Tchem
Family:  Enzyme
Novelty:  0.0108601
p_int:  0.998257037
p_ni:  0.001596583
p_wrong:  0.00014638
Score:  0.189
Data Source:  BioPlex,STRINGDB
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.998135305
p_ni:  0.001838706
p_wrong:  0.000025989
Score:  0.173
Data Source:  BioPlex,STRINGDB
Pathways (306)
Activation of AKT2 (R-HSA-165158)

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Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AKT2
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Activation of AKT2
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Costimulation by the CD28 family
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
4
4
94.4
serum gamma-glutamyl transferase measurement
2
1
2
81.7
2
3
0
1.1
77.1
Eczema
1
1
0
1.1
73.5
1
1
0
1.1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
94.4
serum gamma-glutamyl transferase measurement
2
81.7
0
1.1
77.1
Eczema
0
1.1
73.5
0
1.1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioesterase superfamily member 4
VGNC:10934
457305
Macaque
thioesterase superfamily member 4
711796
Mouse
MGI:1923028
75778
Rat
RGD:1304723
361992
Dog
thioesterase superfamily member 4
VGNC:47341
609163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioesterase superfamily member 4
Macaque
thioesterase superfamily member 4
Mouse
Rat
Dog
thioesterase superfamily member 4
Publication Statistics
PubMed Score 60.62
PubMed score by year
PubTator Score 38.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title