Tbio DCST1 E3 ubiquitin-protein ligase DCST1

Protein Summary

Description

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q5T197
• B4DXA0
• E9PHV3
• Q5T198
• Q6P1W6
• Q71S70
• Q96M70

Gene Name

• DCST1

Ensembl ID

• ENST00000295542
• ENSP00000295542
• ENSG00000163357
• ENST00000368419
• ENSP00000357404
• ENST00000423025
• ENSP00000387369

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.6
cell type or tissue	0.47
gene perturbation	0.44
chemical	0.43
PubMedID	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.52   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.52   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0