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Tbio
MARCH8
E3 ubiquitin-protein ligase MARCH8

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319836
  • ENSP00000317087
  • ENSG00000165406
  • ENST00000395769
  • ENSP00000379116
  • ENST00000395771
  • ENSP00000379118
  • ENSG00000278545
  • ENST00000453424
  • ENSP00000411848

Symbol
  • MIR
  • RNF178
  • MIR
  • CMIR
  • c-MIR
  • RNF178
  • MARCH-VIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.8
virus perturbation
0.76
phenotype
0.72
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.74   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.74   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
7
8
98.5
reticulocyte count
7
5
12
98
reticulocyte measurement
3
5
7
97.9
mean corpuscular volume
7
7
7
97.6
high density lipoprotein cholesterol measurement
5
4
5
95.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
8
98.5
reticulocyte count
12
98
reticulocyte measurement
7
97.9
mean corpuscular volume
7
97.6
high density lipoprotein cholesterol measurement
5
95.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
membrane associated ring-CH-type finger 8
708030
Mouse
MGI:1919029
71779
Rat
RGD:1309339
312656
Horse
membrane associated ring-CH-type finger 8
VGNC:51572
100062110
Cow
membrane associated ring-CH-type finger 8
540667
Species
Name
OMA
EggNOG
Inparanoid
Macaque
membrane associated ring-CH-type finger 8
Mouse
Rat
Horse
membrane associated ring-CH-type finger 8
Cow
membrane associated ring-CH-type finger 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5T0T0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (33)
1 – 10 of 33
UBE2H
Tbio
Novelty:  0.03259425
Score:  0.765
Data Source:  STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
Score:  0.72
Data Source:  STRINGDB
TNFRSF10A
Tchem
Novelty:  0.0003383
Score:  0.712
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.675
Data Source:  STRINGDB
CDC34
Tbio
Novelty:  0.00650407
Score:  0.667
Data Source:  STRINGDB
TFRC
Tbio
Novelty:  0.00025984
Score:  0.665
Data Source:  STRINGDB
WDR82
Tbio
Novelty:  0.04679153
Score:  0.645
Data Source:  STRINGDB
REV1
Tbio
Novelty:  0.00294652
Score:  0.644
Data Source:  STRINGDB
STAP2
Tbio
Novelty:  0.00375696
Score:  0.641
Data Source:  STRINGDB
HLA-DQA2
Tbio
Novelty:  0.00431613
Score:  0.635
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.74

PubMed score by year
PubTator Score  1938.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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