Tbio CELF3 CUGBP Elav-like family member 3

Protein Summary

Description

RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q5SZQ8
• B7ZKK6
• O15414
• Q499Y6
• Q5SZQ7
• Q6NVK0
• Q8IZ98
• Q9BZC2
• Q9HB30
• CELF-3

Gene Name

• CELF3

Ensembl ID

• ENST00000290583
• ENSP00000290583
• ENSG00000159409
• ENST00000290585
• ENSP00000290585

Symbol

• BRUNOL1
• CAGH4
• ERDA4
• TNRC4
• CAGH4
• ERDA4
• ETR-1
• TNRC4
• BRUNOL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.86
gene perturbation	0.78
transcription factor	0.6
cell type or tissue	0.57
tissue	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0