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Tbio
FREM2
FRAS1-related extracellular matrix protein 2

Protein Summary
Description
Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280481
  • ENSP00000280481
  • ENSG00000150893

Symbol
  • FRASRS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
histone modification site profile
0.63
transcription factor binding site profile
0.63
PubMedID
0.62
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
27.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FRAS1 related extracellular matrix protein 2
VGNC:5059
467266
Macaque
FRAS1 related extracellular matrix protein 2
696113
Mouse
MGI:2444465
242022
Rat
RGD:1566012
310418
Dog
FRAS1 related extracellular matrix protein 2
VGNC:40977
486002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FRAS1 related extracellular matrix protein 2
Macaque
FRAS1 related extracellular matrix protein 2
Mouse
Rat
Dog
FRAS1 related extracellular matrix protein 2
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
FAM19A2
Tbio
Novelty: 0.28999346
p_int: 0.99755289
p_ni: 0.00244711
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.993038548
p_ni: 0.006961452
Data Source: BioPlex
FAM19A5
Tdark
Novelty: 0.07792418
p_int: 0.987727072
p_ni: 0.012272928
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.985950735
p_ni: 0.014049265
Data Source: BioPlex
CMA1
Tchem
Family: Enzyme
Novelty: 0.00091144
p_int: 0.979539825
p_ni: 0.020460175
Data Source: BioPlex
UCN3
Tbio
Novelty: 0.00996251
p_int: 0.971794508
p_ni: 0.028205492
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.969883088
p_ni: 0.030116912
Data Source: BioPlex
LAG3
Tbio
Novelty: 0.00187736
p_int: 0.968145653
p_ni: 0.031854347
Data Source: BioPlex
FCGR1A
Tchem
Novelty: 0.00073204
p_int: 0.965645975
p_ni: 0.034354025
Score: 0.183
Data Source: BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.957769176
p_ni: 0.042230824
Data Source: BioPlex
Publication Statistics
PubMed Score  27.26

PubMed score by year
PubTator Score  13.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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