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Tbio
FRMPD1
FERM and PDZ domain-containing protein 1

Protein Summary
Description
Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377765
  • ENSP00000366995
  • ENSG00000070601
  • ENST00000539465
  • ENSP00000444411

Symbol
  • FRMD2
  • KIAA0967
  • FRMD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.82
trait
0.75
small molecule perturbation
0.63
cell type or tissue
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 1
VGNC:14389
464927
Macaque
FERM and PDZ domain containing 1
716380
Mouse
MGI:2446274
666060
Rat
RGD:1305229
313244
Dog
FERM and PDZ domain containing 1
VGNC:51720
481614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 1
Macaque
FERM and PDZ domain containing 1
Mouse
Rat
Dog
FERM and PDZ domain containing 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5SYB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (27)
1 – 10 of 27
FBXO10
Tbio
Novelty: 0.18324932
Score: 0.804
Data Source: STRINGDB
GPSM1
Tbio
Novelty: 0.03510582
Score: 0.781
Data Source: STRINGDB
CLYBL
Tbio
Family: Enzyme
Novelty: 0.02183572
Score: 0.708
Data Source: STRINGDB
TOMM5
Tdark
Novelty: 0.07962801
Score: 0.677
Data Source: STRINGDB
DCAF10
Tdark
Novelty: 2.6713128
Score: 0.668
Data Source: STRINGDB
RIC8A
Tbio
Novelty: 0.01846696
Score: 0.622
Data Source: STRINGDB
CEP112
Tbio
Novelty: 0.27209867
Score: 0.618
Data Source: STRINGDB
TTC29
Tdark
Novelty: 0.1887357
Score: 0.605
Data Source: STRINGDB
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
Score: 0.57
Data Source: STRINGDB
ZIC5
Tbio
Family: TF
Novelty: 0.05269032
Score: 0.568
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.05

PubMed score by year
PubTator Score  4.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer