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Tchem
PPP1R15B
Protein phosphatase 1 regulatory subunit 15B

Protein Summary
Description
Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with micr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367188
  • ENSP00000356156
  • ENSG00000158615

Symbol
  • CREP
  • MSSGM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
microRNA
0.87
virus perturbation
0.83
PubMedID
0.69
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.36   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.36   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (96)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999366458
p_ni:  0.000633473
p_wrong:  6.9e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.999306246
p_ni:  0.00069156
p_wrong:  0.000002194
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.997585076
p_ni:  0.002391428
p_wrong:  0.000023496
Data Source:  BioPlex
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.997492995
p_ni:  0.002419348
p_wrong:  0.000087658
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.994952074
p_ni:  0.005047923
p_wrong:  3e-9
Data Source:  BioPlex
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.990264333
p_ni:  0.006983879
p_wrong:  0.002751789
Data Source:  BioPlex
FGFRL1
Tbio
Novelty:  0.02178846
p_int:  0.988625134
p_ni:  0.0113634
p_wrong:  0.000011466
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.987971189
p_ni:  0.010223613
p_wrong:  0.001805198
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.984779755
p_ni:  0.015100982
p_wrong:  0.000119263
Data Source:  BioPlex
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.958695192
p_ni:  0.025635273
p_wrong:  0.015669535
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
2
1
14.6
89.3
platelet crit
2
2
2
78.9
peak expiratory flow
1
1
1
74.9
educational attainment
2
3
2
41.3
62.8
vital capacity
1
1
1
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
14.6
89.3
platelet crit
2
78.9
peak expiratory flow
1
74.9
educational attainment
2
41.3
62.8
vital capacity
1
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 15B
VGNC:6960
742092
Macaque
protein phosphatase 1 regulatory subunit 15B
699809
Mouse
MGI:2444211
108954
Rat
RGD:1307944
304799
Dog
protein phosphatase 1 regulatory subunit 15B
VGNC:44883
488563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 15B
Macaque
protein phosphatase 1 regulatory subunit 15B
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 15B
Publication Statistics
PubMed Score 35.36
PubMed score by year
PubTator Score 15.62
PubTator score by year
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Related Publications
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PMID
Year
Title