You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LDLRAP1
Low density lipoprotein receptor adapter protein 1

Protein Summary
Description
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374338
  • ENSP00000363458
  • ENSG00000157978

Symbol
  • ARH
  • ARH
  • ARH1
  • ARH2
  • FHCB1
  • FHCB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cellular component
0.81
interacting protein
0.76
transcription factor perturbation
0.74
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.29   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.29   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0