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Tbio
LDLRAP1
Low density lipoprotein receptor adapter protein 1

Protein Summary
Description
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374338
  • ENSP00000363458
  • ENSG00000157978

Symbol
  • ARH
  • ARH
  • ARH1
  • ARH2
  • FHCB1
  • FHCB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cellular component
0.81
interacting protein
0.76
transcription factor perturbation
0.74
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.66   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.66   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (162)
1 – 10 of 162
NLN
Tbio
Family:  Enzyme
Novelty:  0.01217367
p_int:  0.999951303
p_ni:  0.000048697
Score:  0.381
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.998258667
p_ni:  0.001741295
p_wrong:  3.8e-8
Score:  0.284
Data Source:  BioPlex,STRINGDB
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.915932993
p_ni:  0.084067006
Score:  0.205
Data Source:  BioPlex,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.816095766
p_ni:  0.183904234
Score:  0.211
Data Source:  BioPlex,STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.997
Data Source:  STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.991
Data Source:  Reactome,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
Score:  0.98
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.963
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.96
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.939
Data Source:  STRINGDB
Pathways (31)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Chylomicron clearance
Reactome
Clathrin-mediated endocytosis
Reactome
LDL clearance
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Chylomicron clearance
Clathrin-mediated endocytosis
LDL clearance
Membrane Trafficking
Gene Ontology Terms (36)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
5
98
apolipoprotein B measurement
2
3
3
93
low density lipoprotein cholesterol measurement
4
3
4
92.1
platelet count
2
2
2
88
reticulocyte measurement
1
1
1
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
98
apolipoprotein B measurement
3
93
low density lipoprotein cholesterol measurement
4
92.1
platelet count
2
88
reticulocyte measurement
1
84.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
low density lipoprotein receptor adaptor protein 1
739347
Mouse
MGI:2140175
100017
Rat
RGD:1563417
500564
Dog
low density lipoprotein receptor adaptor protein 1
VGNC:42626
612219
Horse
low density lipoprotein receptor adaptor protein 1
VGNC:50712
100071282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
low density lipoprotein receptor adaptor protein 1
Mouse
Rat
Dog
low density lipoprotein receptor adaptor protein 1
Horse
low density lipoprotein receptor adaptor protein 1
Publication Statistics
PubMed Score 61.66
PubMed score by year
PubTator Score 157.74
PubTator score by year