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Tbio
DACT2
Dapper homolog 2

Protein Summary
Description
Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366795
  • ENSP00000355760
  • ENSG00000164488
  • ENST00000366796
  • ENSP00000355761
  • ENST00000607983
  • ENSP00000476434
  • ENST00000610183
  • ENSP00000476573

Symbol
  • C6orf116
  • DPR2
  • DAPPER2
  • C6orf116
  • bA503C24.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
tissue
0.54
PubMedID
0.48
gene perturbation
0.44
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
DACT3
Tbio
Novelty:  0.04684884
Score:  0.867
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.843
Data Source:  STRINGDB
SMOC2
Tbio
Novelty:  0.03698108
Score:  0.658
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.621
Data Source:  STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.612
Data Source:  STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
Score:  0.602
Data Source:  STRINGDB
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
Score:  0.596
Data Source:  STRINGDB
FAM120B
Tbio
Novelty:  0.07982799
Score:  0.557
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.551
Data Source:  STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
6
83.6
BMI-adjusted hip circumference
1
3
3
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
83.6
BMI-adjusted hip circumference
3
63.9
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dishevelled binding antagonist of beta catenin 2
VGNC:11053
742130
Macaque
dishevelled binding antagonist of beta catenin 2
694467
Mouse
MGI:1920347
240025
Rat
RGD:1310742
308212
Dog
dishevelled binding antagonist of beta catenin 2
VGNC:39762
612487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dishevelled binding antagonist of beta catenin 2
Macaque
dishevelled binding antagonist of beta catenin 2
Mouse
Rat
Dog
dishevelled binding antagonist of beta catenin 2
Publication Statistics
PubMed Score 30.61
PubMed score by year
PubTator Score 14.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title