Protein Summary
Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).
- ENST00000366795
- ENSP00000355760
- ENSG00000164488
- ENST00000366796
- ENSP00000355761
- ENST00000607983
- ENSP00000476434
- ENST00000610183
- ENSP00000476573
- C6orf116
- DPR2
- DAPPER2
- C6orf116
- bA503C24.7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue sample | 0.73 | ||
tissue | 0.54 | ||
PubMedID | 0.48 | ||
gene perturbation | 0.44 | ||
cell line | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.61 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 61 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.61 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 61 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (29)
Nearest Tclin Targets
Pathways (3)
PathwayCommons (1)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: pid | TGF-beta receptor signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
TGF-beta receptor signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (5)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 5 | 6 | 83.6 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 63.9 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 6 | 83.6 | |||||
BMI-adjusted hip circumference | 3 | 63.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 2 | VGNC:11053 | 742130 | |||||
Macaque | dishevelled binding antagonist of beta catenin 2 | 694467 | ||||||
Mouse | MGI:1920347 | 240025 | ||||||
Rat | RGD:1310742 | 308212 | ||||||
Dog | dishevelled binding antagonist of beta catenin 2 | VGNC:39762 | 612487 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 2 | |||||
Macaque | dishevelled binding antagonist of beta catenin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dishevelled binding antagonist of beta catenin 2 | |||||
Publication Statistics
PubMed Score 30.61
PubMed score by year
PubTator Score 14.35
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
---|