Tbio DACT2 Dapper homolog 2

Protein Summary

Description

Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

Uniprot Accession IDs

• Q5SW24
• Q2NKJ2
• Q569G0
• Q8WYW2

Gene Name

• DACT2

Ensembl ID

• ENST00000366795
• ENSP00000355760
• ENSG00000164488
• ENST00000366796
• ENSP00000355761
• ENST00000607983
• ENSP00000476434
• ENST00000610183
• ENSP00000476573

Symbol

• C6orf116
• DPR2
• DAPPER2
• C6orf116
• bA503C24.7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.73
tissue	0.54
PubMedID	0.48
gene perturbation	0.44
cell line	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

DACT3

Tbio

Novelty:  0.04684884

Score:  0.867

Data Source:  STRINGDB

DVL2

Tbio

Novelty:  0.00833084

Score:  0.843

Data Source:  STRINGDB

SMOC2

Tbio

Novelty:  0.03698108

Score:  0.658

Data Source:  STRINGDB

TCTE3

Tdark

Novelty:  0.15747856

Score:  0.621

Data Source:  STRINGDB

ACVR1B

Tchem

Family:  Kinase

Novelty:  0.00633595

Score:  0.612

Data Source:  STRINGDB

FRMD1

Tdark

Novelty:  0.96833141

Score:  0.602

Data Source:  STRINGDB

PHF10

Tbio

Family:  Epigenetic

Novelty:  0.05941323

Score:  0.596

Data Source:  STRINGDB

FAM120B

Tbio

Novelty:  0.07982799

Score:  0.557

Data Source:  STRINGDB

DVL1

Tchem

Novelty:  0.00356876

Score:  0.551

Data Source:  STRINGDB

TGFBR1

Tchem

Family:  Kinase

Novelty:  0.00081645

Score:  0.542

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

PathwayCommons (1)

WikiPathways (2)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	TGF-beta receptor signaling	53 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
TGF-beta receptor signaling	53 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (5)

Components (1)

Processes (6)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
delta-catenin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase A binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase C binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
transcription factor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2	5	6		83.6
BMI-adjusted hip circumference	EFO_0008039	1	3	3		63.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	6		83.6
BMI-adjusted hip circumference	EFO_0008039	3		63.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
homeostasis/metabolism phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dishevelled binding antagonist of beta catenin 2	VGNC:11053	742130
Macaque	dishevelled binding antagonist of beta catenin 2		694467
Mouse	dishevelled-binding antagonist of beta-catenin 2	MGI:1920347	240025
Rat	dishevelled-binding antagonist of beta-catenin 2	RGD:1310742	308212
Dog	dishevelled binding antagonist of beta catenin 2	VGNC:39762	612487

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dishevelled binding antagonist of beta catenin 2
Macaque	dishevelled binding antagonist of beta catenin 2
Mouse	dishevelled-binding antagonist of beta-catenin 2
Rat	dishevelled-binding antagonist of beta-catenin 2
Dog	dishevelled binding antagonist of beta catenin 2

Publication Statistics

PubMed Score 30.61

PubMed score by year

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PubTator Score 14.35

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (19)

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10

0 of 0

PMID	Year	Title