You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HP1BP3
Heterochromatin protein 1-binding protein 3

Protein Summary
Description
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312239
  • ENSP00000312625
  • ENSG00000127483
  • ENST00000375000
  • ENSP00000364139
  • ENST00000375003
  • ENSP00000364142

Symbol
  • HP1BP74
  • HP1-BP74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
drug perturbation
0.96
virus perturbation
0.95
small molecule perturbation
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
62
physical activity measurement
1
1
1
48.4
risk-taking behaviour
1
1
1
38.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
62
physical activity measurement
1
48.4
risk-taking behaviour
1
38.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (54)
1 – 10 of 54
IPO7
Tbio
Novelty: 0.01319011
p_int: 0.997781128
p_ni: 0.002218872
Score: 0.165
Data Source: BioPlex,STRINGDB
DDI2
Tbio
Novelty: 0.09288646
p_int: 0.948427884
p_ni: 0.051572116
Score: 0.189
Data Source: BioPlex,STRINGDB
NUSAP1
Tbio
Novelty: 0.01702118
p_int: 0.93058778
p_ni: 0.06941222
Score: 0.315
Data Source: BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.89910919
p_ni: 0.10089081
Data Source: BioPlex
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.896645024
p_ni: 0.103354976
Data Source: BioPlex
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.882717619
p_ni: 0.117282381
Data Source: BioPlex
IPO8
Tbio
Novelty: 0.00934966
p_int: 0.870926819
p_ni: 0.129073181
Data Source: BioPlex
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.854559512
p_ni: 0.145440488
Data Source: BioPlex
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.845139531
p_ni: 0.154860469
Data Source: BioPlex
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.842752109
p_ni: 0.157247891
Data Source: BioPlex
Publication Statistics
PubMed Score  17.08

PubMed score by year
PubTator Score  7.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: