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Tbio
MUC21
Mucin-21

Protein Summary
Description
This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376296
  • ENSP00000365473
  • ENSG00000204544
  • ENST00000549059
  • ENSP00000447840
  • ENSG00000227506

Symbol
  • C6orf205
  • MUC-21
  • KMQK697
  • C6orf205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.69
disease
0.68
cell line
0.59
cellular component
0.52
microRNA
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (74)
1 – 10 of 74
MUC15
Tbio
Novelty:  0.02213624
Score:  0.975
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.975
Data Source:  STRINGDB
MUC12
Tbio
Novelty:  0.04323645
Score:  0.969
Data Source:  STRINGDB
MUC17
Tbio
Novelty:  0.03624836
Score:  0.969
Data Source:  STRINGDB
MUC13
Tbio
Novelty:  0.01282861
Score:  0.967
Data Source:  STRINGDB
MUC3A
Tbio
Novelty:  0.0576775
Score:  0.966
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.965
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.965
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.964
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.96
Data Source:  STRINGDB
Pathways (15)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (80)
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
9
0
1.1
91.2
3
9
0
1.1
91.2
1
7
0
1.1
90.5
1
7
0
1.1
90.5
BMI-adjusted waist-hip ratio
2
10
12
90.4
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.2
0
1.1
91.2
0
1.1
90.5
0
1.1
90.5
BMI-adjusted waist-hip ratio
12
90.4
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Publication Statistics
PubMed Score 41.86
PubMed score by year
PubTator Score 14.84
PubTator score by year