You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MUC21
Mucin-21

Protein Summary
Description
This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376296
  • ENSP00000365473
  • ENSG00000204544
  • ENST00000549059
  • ENSP00000447840
  • ENSG00000227506

Symbol
  • C6orf205
  • MUC-21
  • KMQK697
  • C6orf205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.69
disease
0.68
cell line
0.59
cellular component
0.52
microRNA
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5SSG8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
MUC15
Tbio
Novelty: 0.02213624
Score: 0.975
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.975
Data Source: STRINGDB
MUC12
Tbio
Novelty: 0.04323645
Score: 0.969
Data Source: STRINGDB
MUC17
Tbio
Novelty: 0.03624836
Score: 0.969
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.967
Data Source: STRINGDB
MUC3A
Tbio
Novelty: 0.0576775
Score: 0.966
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.965
Data Source: STRINGDB
MUC16
Tbio
Novelty: 0.00444587
Score: 0.965
Data Source: STRINGDB
MUC4
Tbio
Novelty: 0.00193208
Score: 0.964
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.32

PubMed score by year
PubTator Score  14.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer