You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MANEA
Glycoprotein endo-alpha-1,2-mannosidase

Protein Summary
Description
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
pathway
0.78
cell type or tissue
0.68
microRNA
0.66
small molecule perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.86   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
OLFM1
Tbio
Novelty:  0.02210029
p_int:  0.999961139
p_ni:  0.000038861
Score:  0.192
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999659198
p_ni:  0.000340802
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.997968389
p_ni:  0.002031611
Data Source:  BioPlex
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
p_int:  0.997717642
p_ni:  0.002282354
p_wrong:  4e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.995355553
p_ni:  0.004644446
Data Source:  BioPlex
CLU
Tbio
Novelty:  0.00054776
p_int:  0.986496196
p_ni:  0.013503804
Data Source:  BioPlex
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
p_int:  0.974421375
p_ni:  0.025578625
Score:  0.16
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.96115638
p_ni:  0.03884362
Data Source:  BioPlex
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
p_int:  0.929812105
p_ni:  0.07018788
p_wrong:  1.5e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
TRHDE
Tbio
Family:  Enzyme
Novelty:  0.02084006
p_int:  0.928753666
p_ni:  0.071241822
p_wrong:  0.000004512
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming and elongation in the cis-Golgi
Reactome
Post-translational protein modification
Reactome
Transport to the Golgi and subsequent modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming and elongation in the cis-Golgi
Post-translational protein modification
Transport to the Golgi and subsequent modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
27.5
sex hormone-binding globulin measurement
2
2
2
17.9
aspartate aminotransferase measurement
1
1
0
5.9
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
27.5
sex hormone-binding globulin measurement
2
17.9
aspartate aminotransferase measurement
0
5.9
1.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase endo-alpha
VGNC:8722
472074
Macaque
mannosidase endo-alpha
708164
Mouse
MGI:2444484
242362
Rat
RGD:620327
140808
Dog
mannosidase endo-alpha
VGNC:42950
481925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase endo-alpha
Macaque
mannosidase endo-alpha
Mouse
Rat
Dog
mannosidase endo-alpha
Publication Statistics
PubMed Score 39.86
PubMed score by year
PubTator Score 97.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title