Tbio PHYHD1 Phytanoyl-CoA dioxygenase domain-containing protein 1

Protein Summary

Description

Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity.

Uniprot Accession IDs

• Q5SRE7
• A6PWN9
• A6PWP0
• B3KT57
• B4E3X8
• Q5SRE9
• Q5SRF0
• Q7Z623
• Q7Z7P9
• Q96GM4

Gene Name

• PHYHD1

Ensembl ID

• ENST00000308941
• ENSP00000309515
• ENSG00000175287
• ENST00000353176
• ENSP00000340945
• ENST00000372592
• ENSP00000361673
• ENST00000421063
• ENSP00000409928

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
virus perturbation	0.72
disease perturbation	0.62
small molecule perturbation	0.51
cell type or tissue	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0