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Tbio
NUP188
Nucleoporin NUP188 homolog

Protein Summary
Description
May function as a component of the nuclear pore complex (NPC). The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372577
  • ENSP00000361658
  • ENSG00000095319

Symbol
  • KIAA0169
  • hNup188
  • KIAA0169
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
pathway
0.99
kinase perturbation
0.98
drug perturbation
0.96
interacting protein
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
NUP93
Tbio
Novelty:  0.0248311
Score:  0.999
Data Source:  STRINGDB
NUP155
Tbio
Novelty:  0.03884486
Score:  0.998
Data Source:  STRINGDB
NUP205
Tbio
Novelty:  0.06778513
Score:  0.997
Data Source:  STRINGDB
NUP62
Tbio
Novelty:  0.01432724
Score:  0.994
Data Source:  STRINGDB
NUP54
Tbio
Novelty:  0.08155008
Score:  0.99
Data Source:  STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.988
Data Source:  STRINGDB
NUP35
Tbio
Novelty:  0.0355102
Score:  0.984
Data Source:  STRINGDB
NUP160
Tbio
Novelty:  0.03667026
Score:  0.98
Data Source:  STRINGDB
NUP133
Tbio
Novelty:  0.02115225
Score:  0.978
Data Source:  STRINGDB
NUP153
Tbio
Novelty:  0.00696568
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
4
86.8
metabolite measurement
1
1
1
83.2
red blood cell distribution width
2
1
2
74.5
red blood cell density measurement
1
1
1
53.3
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
86.8
metabolite measurement
1
83.2
red blood cell distribution width
2
74.5
red blood cell density measurement
1
53.3
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 188
VGNC:4814
464912
Macaque
nucleoporin 188
722580
Mouse
MGI:2446190
227699
Rat
RGD:1306022
366016
Dog
nucleoporin 188
VGNC:44048
491307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 188
Macaque
nucleoporin 188
Mouse
Rat
Dog
nucleoporin 188
Publication Statistics
PubMed Score 14.29
PubMed score by year
PubTator Score 4.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title