NUP188
Nucleoporin NUP188 homolog
Protein Summary
May function as a component of the nuclear pore complex (NPC). The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
- ENST00000372577
- ENSP00000361658
- ENSG00000095319
- KIAA0169
- hNup188
- KIAA0169
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
pathway | 0.99 | ||
kinase perturbation | 0.98 | ||
drug perturbation | 0.96 | ||
interacting protein | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.29 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.29 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (155)
Nearest Tclin Targets
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 1 | 4 | 86.8 | |||||
metabolite measurement | 1 | 1 | 1 | 83.2 | |||||
red blood cell distribution width | 2 | 1 | 2 | 74.5 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.3 | |||||
1 | 1 | 0 | 1.1 | 31.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood metabolite measurement | 4 | 86.8 | |||||
metabolite measurement | 1 | 83.2 | |||||
red blood cell distribution width | 2 | 74.5 | |||||
red blood cell density measurement | 1 | 53.3 | |||||
0 | 1.1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 188 | VGNC:4814 | 464912 | |||||
Macaque | nucleoporin 188 | 722580 | ||||||
Mouse | MGI:2446190 | 227699 | ||||||
Rat | RGD:1306022 | 366016 | ||||||
Dog | nucleoporin 188 | VGNC:44048 | 491307 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleoporin 188 | |||||
Macaque | nucleoporin 188 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleoporin 188 | |||||
Publication Statistics
PubMed Score 14.29
PubMed score by year
PubTator Score 4.84
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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