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Tdark
SH2D4B
SH2 domain-containing protein 4B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313455
  • ENSP00000314242
  • ENSG00000178217
  • ENST00000339284
  • ENSP00000345295
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
cell type or tissue
0.77
transcription factor
0.73
transcription factor binding site profile
0.7
microRNA
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
DYDC2
Tdark
Novelty:  1.40061645
Score:  0.722
Data Source:  STRINGDB
DYDC1
Tdark
Novelty:  0.35666983
Score:  0.717
Data Source:  STRINGDB
LAX1
Tbio
Novelty:  0.00303728
Score:  0.635
Data Source:  STRINGDB
TSPAN14
Tdark
Novelty:  0.31693614
Score:  0.583
Data Source:  STRINGDB
UBOX5
Tbio
Novelty:  0.37436118
Score:  0.573
Data Source:  STRINGDB
FCHSD2
Tbio
Novelty:  0.01879431
Score:  0.557
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.557
Data Source:  STRINGDB
CTC1
Tbio
Novelty:  0.01298038
Score:  0.557
Data Source:  STRINGDB
TMEM254
Tdark
Novelty:  2.62080439
Score:  0.553
Data Source:  STRINGDB
SHQ1
Tbio
Novelty:  0.09779957
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
77
monocyte count
1
1
1
70.5
1
1
0
1.1
69.8
myeloid white cell count
1
1
1
68.8
pulse pressure measurement
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77
monocyte count
1
70.5
0
1.1
69.8
myeloid white cell count
1
68.8
pulse pressure measurement
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 4B
VGNC:5727
466129
Macaque
SH2 domain containing 4B
699761
Mouse
MGI:1925182
328381
Rat
RGD:1311591
290612
Dog
SH2 domain containing 4B
VGNC:46115
479262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 4B
Macaque
SH2 domain containing 4B
Mouse
Rat
Dog
SH2 domain containing 4B
Publication Statistics
PubMed Score 0.50
PubMed score by year
PubTator Score 0.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title