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Tbio
ATAT1
Alpha-tubulin N-acetyltransferase 1

Protein Summary
Description
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318999
  • ENSP00000324222
  • ENSG00000137343
  • ENST00000319027
  • ENSP00000324459
  • ENST00000329992
  • ENSP00000332374
  • ENST00000330083
  • ENSP00000327832
  • ENST00000376483
  • ENSP00000365666
  • ENST00000376485
  • ENSP00000365668
  • ENST00000383582
  • ENSP00000373076
  • ENSG00000206488
  • ENST00000383583
  • ENSP00000373077
  • ENST00000383584
  • ENSP00000373078
  • ENST00000383585
  • ENSP00000373079
  • ENST00000400575
  • ENSP00000383419
  • ENST00000400576
  • ENSP00000383420
  • ENST00000411724
  • ENSP00000388617
  • ENSG00000234549
  • ENST00000416435
  • ENSP00000412993
  • ENSG00000235658
  • ENST00000416917
  • ENSP00000402998
  • ENST00000417183
  • ENSP00000393868
  • ENSG00000231257
  • ENST00000418248
  • ENSP00000411362
  • ENST00000420586
  • ENSP00000411050
  • ENST00000423338
  • ENSP00000415000
  • ENSG00000223752
  • ENST00000423654
  • ENSP00000403142
  • ENST00000424121
  • ENSP00000412198
  • ENST00000425448
  • ENSP00000391244
  • ENST00000428764
  • ENSP00000399509
  • ENST00000430611
  • ENSP00000409296
  • ENST00000432356
  • ENSP00000416994
  • ENST00000432643
  • ENSP00000416925
  • ENST00000442844
  • ENSP00000394914
  • ENST00000443114
  • ENSP00000405656
  • ENSG00000229061
  • ENST00000443391
  • ENSP00000406071
  • ENST00000445486
  • ENSP00000398422
  • ENST00000445973
  • ENSP00000415408
  • ENST00000446100
  • ENSP00000393269
  • ENST00000448670
  • ENSP00000389129
  • ENST00000449905
  • ENSP00000399529
  • ENST00000450003
  • ENSP00000406421
  • ENST00000450220
  • ENSP00000405036
  • ENST00000454794
  • ENSP00000409067
  • ENST00000454987
  • ENSP00000410415
  • ENST00000456215
  • ENSP00000399452
  • ENST00000456704
  • ENSP00000394357
  • ENST00000457161
  • ENSP00000388171
  • ENST00000457334
  • ENSP00000398374

Symbol
  • C6orf134
  • MEC17
  • TAT
  • MEC17
  • C6orf134
  • Nbla00487
  • alpha-TAT
  • alpha-TAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
virus perturbation
0.76
small molecule perturbation
0.66
microRNA
0.62
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.67   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.67   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
28.8
1
1
0
1.1
28.8
1
1
0
1.1
28.8
1
1
0
1.1
28.8
1
1
0
1.1
28.8
Items per page:
1 – 5 of 21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
28.8
0
1.1
28.8
0
1.1
28.8
0
1.1
28.8
0
1.1
28.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alpha tubulin acetyltransferase 1
100141388
Mouse
MGI:1913869
73242
Rat
RGD:1303066
361789
Dog
alpha tubulin acetyltransferase 1
VGNC:38204
477580
Horse
alpha tubulin acetyltransferase 1
VGNC:15606
100055595
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alpha tubulin acetyltransferase 1
Mouse
Rat
Dog
alpha tubulin acetyltransferase 1
Horse
alpha tubulin acetyltransferase 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5SQI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Organelle biogenesis and maintenance
Protein-Protein Interactions (33)
1 – 10 of 33
HERC1
Tbio
Family: Enzyme
Novelty: 0.04318441
p_int: 0.997771099
p_ni: 0.002228901
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.954874272
p_ni: 4.1e-8
p_wrong: 0.045125688
Score: 0.187
Data Source: BioPlex,STRINGDB
DOCK7
Tbio
Novelty: 0.03425586
p_int: 0.892247157
p_ni: 0.107752843
Data Source: BioPlex
VWF
Tbio
Novelty: 0.00009007
Score: 0.799
Data Source: STRINGDB
F8
Tbio
Novelty: 0.0002287
Score: 0.797
Data Source: STRINGDB
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
Score: 0.767
Data Source: STRINGDB
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
Score: 0.757
Data Source: STRINGDB
BSCL2
Tbio
Novelty: 0.00483959
Score: 0.624
Data Source: STRINGDB
ELP3
Tbio
Family: Epigenetic
Novelty: 0.0166061
Score: 0.605
Data Source: STRINGDB
TBCEL
Tdark
Novelty: 0.71768573
Score: 0.6
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.67

PubMed score by year
PubTator Score  22.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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