ATAT1
Alpha-tubulin N-acetyltransferase 1
Protein Summary
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on ...more
- ENST00000318999
- ENSP00000324222
- ENSG00000137343
- ENST00000319027
- ENSP00000324459
- ENST00000329992
- ENSP00000332374
- ENST00000330083
- ENSP00000327832
- ENST00000376483
- ENSP00000365666
- ENST00000376485
- ENSP00000365668
- ENST00000383582
- ENSP00000373076
- ENSG00000206488
- ENST00000383583
- ENSP00000373077
- ENST00000383584
- ENSP00000373078
- ENST00000383585
- ENSP00000373079
- ENST00000400575
- ENSP00000383419
- ENST00000400576
- ENSP00000383420
- ENST00000411724
- ENSP00000388617
- ENSG00000234549
- ENST00000416435
- ENSP00000412993
- ENSG00000235658
- ENST00000416917
- ENSP00000402998
- ENST00000417183
- ENSP00000393868
- ENSG00000231257
- ENST00000418248
- ENSP00000411362
- ENST00000420586
- ENSP00000411050
- ENST00000423338
- ENSP00000415000
- ENSG00000223752
- ENST00000423654
- ENSP00000403142
- ENST00000424121
- ENSP00000412198
- ENST00000425448
- ENSP00000391244
- ENST00000428764
- ENSP00000399509
- ENST00000430611
- ENSP00000409296
- ENST00000432356
- ENSP00000416994
- ENST00000432643
- ENSP00000416925
- ENST00000442844
- ENSP00000394914
- ENST00000443114
- ENSP00000405656
- ENSG00000229061
- ENST00000443391
- ENSP00000406071
- ENST00000445486
- ENSP00000398422
- ENST00000445973
- ENSP00000415408
- ENST00000446100
- ENSP00000393269
- ENST00000448670
- ENSP00000389129
- ENST00000449905
- ENSP00000399529
- ENST00000450003
- ENSP00000406421
- ENST00000450220
- ENSP00000405036
- ENST00000454794
- ENSP00000409067
- ENST00000454987
- ENSP00000410415
- ENST00000456215
- ENSP00000399452
- ENST00000456704
- ENSP00000394357
- ENST00000457161
- ENSP00000388171
- ENST00000457334
- ENSP00000398374
- C6orf134
- MEC17
- TAT
- MEC17
- C6orf134
- Nbla00487
- alpha-TAT
- alpha-TAT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.79 | ||
virus perturbation | 0.76 | ||
small molecule perturbation | 0.66 | ||
microRNA | 0.62 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.53 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 99 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.53 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 99 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0