Tbio PPM1L Protein phosphatase 1L

Protein Summary

Description

Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q5SGD2
• Q2M3J2
• Q96NM7

Gene Name

• PPM1L

Ensembl ID

• ENST00000295839
• ENSP00000295839
• ENSG00000163590
• ENST00000464260
• ENSP00000420746
• ENST00000497343
• ENSP00000420354
• ENST00000498165
• ENSP00000417659

Symbol

• PP2CE
• PP2CE
• PPM1-LIKE
• PP2C-epsilon

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor binding site profile	0.84
transcription factor perturbation	0.84
virus perturbation	0.79
small molecule perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1l

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Protein Phosphatase 1l

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1l

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.2   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.2   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0