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Tchem
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

Protein Summary
Description
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. Plays an important role in recuiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). This gene is a member of the leucine-rich repeat kinase family and encodes a pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298910
  • ENSP00000298910
  • ENSG00000188906

Symbol
  • PARK8
  • PARK8
  • RIPK7
  • ROCO2
  • AURA17
  • DARDARIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
cellular component
0.93
drug perturbation
0.87


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1816.03   (req: < 5)
Gene RIFs: 741   (req: <= 3)
Antibodies: 804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1816.03   (req: >= 5)
Gene RIFs: 741   (req: > 3)
Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 859
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
0
1.3
99.3
2
2
0
1.3
91.4
mean platelet volume
2
2
2
79.1
1
1
0
1.1
70.1
cathepsin L1 measurement
1
1
1
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
99.3
0
1.3
91.4
mean platelet volume
2
79.1
0
1.1
70.1
cathepsin L1 measurement
1
69.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat kinase 2
VGNC:13210
745893
Macaque
leucine rich repeat kinase 2
697930
Mouse
MGI:1913975
66725
Rat
RGD:1561168
300160
Dog
leucine rich repeat kinase 2
VGNC:42823
486608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat kinase 2
Macaque
leucine rich repeat kinase 2
Mouse
Rat
Dog
leucine rich repeat kinase 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5S007-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
PTK6 promotes HIF1A stabilization (R-HSA-8857538)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 promotes HIF1A stabilization
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 promotes HIF1A stabilization
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (161)
Items per page:
10
1 – 10 of 24
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (445)
1 – 10 of 445
PRKN
Tbio
Family: Enzyme
Novelty: 0.00079898
Score: 0.978
Data Source: STRINGDB
SNCA
Tchem
Novelty: 0.00012042
Score: 0.971
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.966
Data Source: STRINGDB
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.958
Data Source: STRINGDB
SFN
Tbio
Novelty: 0.00340233
Score: 0.955
Data Source: STRINGDB
HIF1A
Tchem
Family: TF
Novelty: 0.00011503
Score: 0.941
Data Source: Reactome,STRINGDB
VPS35
Tbio
Novelty: 0.00729892
Score: 0.941
Data Source: STRINGDB
GPNMB
Tbio
Novelty: 0.00618732
Score: 0.936
Data Source: Reactome,STRINGDB
RAB29
Tchem
Family: Enzyme
Novelty: 0.03751616
Score: 0.93
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.921
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1816.03

PubMed score by year
PubTator Score  1206.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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