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Tchem
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

Protein Summary
Description
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. Plays an important role in recuiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). This gene is a member of the leucine-rich repeat kinase family and encodes a pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298910
  • ENSP00000298910
  • ENSG00000188906

Symbol
  • PARK8
  • PARK8
  • RIPK7
  • ROCO2
  • AURA17
  • DARDARIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
cellular component
0.93
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2119.59   (req: < 5)
Gene RIFs: 741   (req: <= 3)
Antibodies: 804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2119.59   (req: >= 5)
Gene RIFs: 741   (req: > 3)
Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1022
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2