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Tbio
EXOSC6
Exosome complex component MTR3

Protein Summary
Description
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435634
  • ENSP00000398597
  • ENSG00000223496

Symbol
  • MTR3
  • p11
  • EAP4
  • MTR3
  • Mtr3p
  • hMtr3p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor binding site profile
0.79
kinase perturbation
0.71
protein complex
0.65
hub protein
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
59.9
self reported educational attainment
1
1
1
35
urate measurement
1
1
1
30.2
amino acid measurement
1
1
1
21.5
apolipoprotein B measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
59.9
self reported educational attainment
1
35
urate measurement
1
30.2
amino acid measurement
1
21.5
apolipoprotein B measurement
1
21.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exosome component 6
VGNC:5760
468014
Mouse
MGI:1919794
72544
Rat
RGD:1309832
307850
Pig
exosome component 6
100737302
Opossum
exosome component 6 [Source:HGNC Symbol;Acc:HGNC:19055]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exosome component 6
Mouse
Rat
Pig
exosome component 6
Opossum
exosome component 6 [Source:HGNC Symbol;Acc:HGNC:19055]
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5RKV6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (204)
1 – 10 of 204
C1D
Tbio
Novelty:  0.00997109
p_int:  0.988815858
p_ni:  0.011184142
Score:  0.998
Data Source:  BioPlex,STRINGDB
EXOSC1
Tbio
Novelty:  0.01386842
p_int:  0.986754588
p_ni:  0.013245412
Score:  0.999
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.971260094
p_ni:  0.028739906
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.961638268
p_ni:  0.038361732
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  0.955975734
p_ni:  0.044024266
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
Score:  0.999
Data Source:  STRINGDB
EXOSC5
Tbio
Family:  Enzyme
Novelty:  0.03352493
Score:  0.999
Data Source:  STRINGDB
EXOSC9
Tbio
Family:  Enzyme
Novelty:  0.02405093
Score:  0.999
Data Source:  STRINGDB
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.999
Data Source:  STRINGDB
DIS3L
Tbio
Family:  Enzyme
Novelty:  0.12886408
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.75

PubMed score by year
PubTator Score  29.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer