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Tbio
RABGAP1L
Rab GTPase-activating protein 1-like

Protein Summary
Description
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251507
  • ENSP00000251507
  • ENSG00000152061
  • ENST00000325589
  • ENSP00000318603
  • ENST00000347255
  • ENSP00000281844
  • ENST00000357444
  • ENSP00000350027
  • ENST00000367687
  • ENSP00000356660
  • ENST00000478442
  • ENSP00000434600
  • ENST00000486220
  • ENSP00000432490
  • ENST00000489615
  • ENSP00000420660

Symbol
  • HHL
  • KIAA0471
  • HHL
  • TBC1D18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.98
virus perturbation
0.94
PubMedID
0.9
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
4
91.9
chronotype measurement
2
1
4
91.9
body mass index
2
2
4
90.2
body mass index
2
2
4
90.2
mathematical ability
1
1
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
91.9
chronotype measurement
4
91.9
body mass index
4
90.2
body mass index
4
90.2
mathematical ability
2
83
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB GTPase activating protein 1 like
VGNC:11811
457532
Macaque
RAB GTPase activating protein 1 like
708179
Mouse
MGI:1352507
29809
Rat
RGD:1304620
304914
Horse
RAB GTPase activating protein 1 like [Source:HGNC Symbol;Acc:HGNC:24663]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB GTPase activating protein 1 like
Macaque
RAB GTPase activating protein 1 like
Mouse
Rat
Horse
RAB GTPase activating protein 1 like [Source:HGNC Symbol;Acc:HGNC:24663]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5R372-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (39)
1 – 10 of 39
WFIKKN1
Tbio
Novelty: 0.09604321
Score: 0.791
Data Source: STRINGDB
RAB22A
Tbio
Family: Enzyme
Novelty: 0.02344687
Score: 0.731
Data Source: STRINGDB
RAB34
Tbio
Novelty: 0.03645677
Score: 0.722
Data Source: STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.03645677
Score: 0.722
Data Source: STRINGDB
TBC1D13
Tdark
Novelty: 0.60353273
Score: 0.68
Data Source: STRINGDB
TBCC
Tbio
Novelty: 0.07928844
Score: 0.637
Data Source: STRINGDB
TBC1D23
Tbio
Novelty: 0.18566729
Score: 0.631
Data Source: STRINGDB
PTCRA
Tbio
Novelty: 0.01307489
Score: 0.628
Data Source: STRINGDB
TBC1D20
Tbio
Novelty: 0.08651866
Score: 0.627
Data Source: STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
Score: 0.623
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.57

PubMed score by year
PubTator Score  6.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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