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Tbio
Q5R372
Rab GTPase-activating protein 1-like

Protein Summary
Description
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251507
  • ENSP00000251507
  • ENSG00000152061
  • ENST00000325589
  • ENSP00000318603
  • ENST00000347255
  • ENSP00000281844
  • ENST00000357444
  • ENSP00000350027
  • ENST00000367687
  • ENSP00000356660
  • ENST00000478442
  • ENSP00000434600
  • ENST00000486220
  • ENSP00000432490
  • ENST00000489615
  • ENSP00000420660

Symbol
  • HHL
  • KIAA0471
  • HHL
  • TBC1D18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.98
virus perturbation
0.94
PubMedID
0.9
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0