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Tdark
HIST2H2BF
Histone H2B type 2-F

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369167
  • ENSP00000358164
  • ENSG00000203814
  • ENST00000545683
  • ENSP00000445831
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.83
microRNA
0.74
histone modification site profile
0.7
cell line
0.62
interacting protein
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
62.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
62.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5QNW6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (110)
1 – 10 of 110
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.999999956
p_ni: 4.1e-8
p_wrong: 3e-9
Data Source: BioPlex
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.999999358
p_ni: 4.9e-8
p_wrong: 5.93e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
RPL10A
Tbio
Novelty: 0.01747453
p_int: 0.999999189
p_ni: 3.6e-8
p_wrong: 7.75e-7
Score: 0.832
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.999998581
p_ni: 7e-9
p_wrong: 0.000001412
Score: 0.187
Data Source: BioPlex,STRINGDB
HIST2H2AA3
Tbio
Novelty: 0.00065445
Score: 0.995
Data Source: STRINGDB
HIST1H2BO
Tdark
Novelty: 0.3427419
Score: 0.994
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.99
Data Source: STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
Score: 0.99
Data Source: STRINGDB
HIST1H2AC
Tdark
Novelty: 0.4785744
Score: 0.98
Data Source: STRINGDB
HIST3H2A
Tbio
Novelty: 0.34036249
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.49

PubMed score by year
PubTator Score  0.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer