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Tdark
DNTTIP2
Deoxynucleotidyltransferase terminal-interacting protein 2

Protein Summary
Description
Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436063
  • ENSP00000411010
  • ENSG00000067334

Symbol
  • ERBP
  • TDIF2
  • ERBP
  • FCF2
  • TdIF2
  • HSU15552
  • LPTS-RP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
cell type or tissue
0.9
transcription factor binding site profile
0.84
histone modification site profile
0.76
virus perturbation
0.76


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxynucleotidyltransferase terminal interacting protein 2
VGNC:9851
100614853
Macaque
deoxynucleotidyltransferase terminal interacting protein 2
106999757
Mouse
MGI:1923173
99480
Rat
RGD:6497192
100910753
Dog
deoxynucleotidyltransferase terminal interacting protein 2
VGNC:40041
490154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxynucleotidyltransferase terminal interacting protein 2
Macaque
deoxynucleotidyltransferase terminal interacting protein 2
Mouse
Rat
Dog
deoxynucleotidyltransferase terminal interacting protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5QJE6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (192)
1 – 10 of 192
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.979274945
p_ni:  0.020494437
p_wrong:  0.000230618
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.960055096
p_ni:  0.039925811
p_wrong:  0.000019093
Data Source:  BioPlex
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.956668952
p_ni:  0.04327257
p_wrong:  0.000058478
Score:  0.163
Data Source:  BioPlex,STRINGDB
NIFK
Tbio
Novelty:  0.01221562
p_int:  0.937312127
p_ni:  0.030943653
p_wrong:  0.03174422
Score:  0.958
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.891885596
p_ni:  0.107956726
p_wrong:  0.000157678
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.874887105
p_ni:  0.037727019
p_wrong:  0.087385876
Data Source:  BioPlex
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.79545197
p_ni:  0.049297795
p_wrong:  0.155250235
Score:  0.297
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
Score:  0.992
Data Source:  STRINGDB
UTP11
Tbio
Novelty:  0.20711838
Score:  0.991
Data Source:  STRINGDB
DCAF13
Tbio
Novelty:  0.02796363
Score:  0.988
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.54

PubMed score by year
PubTator Score  17.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer