Tdark DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2

Protein Summary

Description

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q5QJE6
• Q12987
• Q53H59
• Q5TFJ4
• Q6TLI0
• Q76MJ8
• Q86WX9

Gene Name

• DNTTIP2

Ensembl ID

• ENST00000436063
• ENSP00000411010
• ENSG00000067334

Symbol

• ERBP
• TDIF2
• ERBP
• FCF2
• TdIF2
• HSU15552
• LPTS-RP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
cell type or tissue	0.9
transcription factor binding site profile	0.84
histone modification site profile	0.76
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.79   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 17   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.79   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0