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Tbio
CLEC12A
C-type lectin domain family 12 member A

Protein Summary
Description
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304361
  • ENSP00000302804
  • ENSG00000172322
  • ENST00000350667
  • ENSP00000345448
  • ENST00000355690
  • ENSP00000347916
  • ENST00000434319
  • ENSP00000405244

Symbol
  • CLL1
  • DCAL2
  • MICL
  • CLL1
  • MICL
  • CD371
  • CLL-1
  • DCAL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
tissue sample
0.59
cell line
0.54
tissue
0.49
biological term
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.06   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.06   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 12 member A
VGNC:8369
737508
Macaque
C-type lectin domain family 12 member A
722319
Mouse
MGI:3040968
232413
Rat
RGD:1592991
680338
Dog
C-type lectin domain family 12 member A
VGNC:39325
477697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 12 member A
Macaque
C-type lectin domain family 12 member A
Mouse
Rat
Dog
C-type lectin domain family 12 member A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5QGZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (200)
1 – 10 of 200
VTI1A
Tbio
Novelty: 0.04616617
p_int: 0.999995342
p_ni: 0.000004657
p_wrong: 1e-9
Score: 0.707
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999981303
p_ni: 0.000018695
p_wrong: 2e-9
Score: 0.632
Data Source: BioPlex,STRINGDB
GOSR2
Tbio
Novelty: 0.02447711
p_int: 0.999907713
p_ni: 0.000092262
p_wrong: 2.5e-8
Score: 0.668
Data Source: BioPlex,STRINGDB
SOX13
Tbio
Family: TF
Novelty: 0.02397048
p_int: 0.999798263
p_ni: 0.000201723
p_wrong: 1.3e-8
Score: 0.205
Data Source: BioPlex,STRINGDB
XPO5
Tbio
Novelty: 0.0040002
p_int: 0.999771535
p_ni: 0.000228465
Score: 0.205
Data Source: BioPlex,STRINGDB
STX5
Tbio
Novelty: 0.00964918
p_int: 0.999284317
p_ni: 0.000715683
Score: 0.513
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.0259034
p_int: 0.9976891
p_ni: 0.0023109
Score: 0.613
Data Source: BioPlex,STRINGDB
MESD
Tbio
Novelty: 0.02639297
p_int: 0.997589445
p_ni: 0.002410554
p_wrong: 1e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
STX10
Tbio
Novelty: 0.05193552
p_int: 0.996541019
p_ni: 0.00345887
p_wrong: 1.11e-7
Score: 0.671
Data Source: BioPlex,STRINGDB
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.993158572
p_ni: 0.006841428
Data Source: BioPlex
Publication Statistics
PubMed Score  79.06

PubMed score by year
PubTator Score  45.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer