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Tbio
CLEC12A
C-type lectin domain family 12 member A

Protein Summary
Description
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304361
  • ENSP00000302804
  • ENSG00000172322
  • ENST00000350667
  • ENSP00000345448
  • ENST00000355690
  • ENSP00000347916
  • ENST00000434319
  • ENSP00000405244

Symbol
  • CLL1
  • DCAL2
  • MICL
  • CLL1
  • MICL
  • CD371
  • CLL-1
  • DCAL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
tissue sample
0.59
cell line
0.54
tissue
0.49
biological term
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0