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Tchem
FFAR4
Free fatty acid receptor 4

Protein Summary
Description
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371481
  • ENSP00000360536
  • ENSG00000186188
  • ENST00000371483
  • ENSP00000360538

Symbol
  • GPR120
  • GPR129
  • O3FAR1
  • PGR4
  • GT01
  • PGR4
  • BMIQ10
  • GPR120
  • GPR129
  • O3FAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
tissue
0.75
gene perturbation
0.71
molecular function
0.67
cell type or tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.12   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.12   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
1
2
89.8
vitamin A measurement
1
1
1
83.4
waist-hip ratio
2
1
2
73.1
reticulocyte count
1
1
1
10.7
optic disc area measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
89.8
vitamin A measurement
1
83.4
waist-hip ratio
2
73.1
reticulocyte count
1
10.7
optic disc area measurement
1
5.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 4
VGNC:3856
740365
Macaque
free fatty acid receptor 4
700014
Mouse
MGI:2147577
107221
Rat
RGD:1308252
294075
Dog
free fatty acid receptor 4
VGNC:40832
477774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 4
Macaque
free fatty acid receptor 4
Mouse
Rat
Dog
free fatty acid receptor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5NUL3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Free fatty acid receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Free fatty acid receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (218)
1 – 10 of 218
FFAR1
Tchem
Family: GPCR
Novelty: 0.00271782
Score: 0.992
Data Source: STRINGDB
FFAR3
Tchem
Family: GPCR
Novelty: 0.00746169
Score: 0.982
Data Source: STRINGDB
FFAR2
Tchem
Family: GPCR
Novelty: 0.00361123
Score: 0.981
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.965
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.953
Data Source: STRINGDB
GPRC6A
Tchem
Family: GPCR
Novelty: 0.01625616
Score: 0.948
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.945
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00061316
Score: 0.943
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.94
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  270.12

PubMed score by year
PubTator Score  110.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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