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Tbio
ENTPD8
Ectonucleoside triphosphate diphosphohydrolase 8

Protein Summary
Description
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344119
  • ENSP00000344089
  • ENSG00000188833
  • ENST00000371506
  • ENSP00000360561
  • ENST00000472938
  • ENSP00000420531

Symbol
  • UNQ2492
  • GLSR2492
  • E-NTPDase
  • NTPDase-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cell line
0.63
cell type or tissue
0.57
cellular component
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.37   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.37   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0