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Tbio
ENTPD8
Ectonucleoside triphosphate diphosphohydrolase 8

Protein Summary
Description
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344119
  • ENSP00000344089
  • ENSG00000188833
  • ENST00000371506
  • ENSP00000360561
  • ENST00000472938
  • ENSP00000420531

Symbol
  • UNQ2492
  • GLSR2492
  • E-NTPDase
  • NTPDase-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cell line
0.63
cell type or tissue
0.57
cellular component
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.967
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.953
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.941
Data Source:  STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
Score:  0.937
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.937
Data Source:  STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
Score:  0.933
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.926
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.925
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.922
Data Source:  STRINGDB
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets (42)
Explore Nearest Tclin Targets
1 – 5 of 30
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  3
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  3
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
90.8
mathematical ability
4
2
4
85.2
self reported educational attainment
1
1
1
72.6
insomnia measurement
1
1
0
1.1
62.8
cognitive function measurement
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
90.8
mathematical ability
4
85.2
self reported educational attainment
1
72.6
insomnia measurement
0
1.1
62.8
cognitive function measurement
1
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 8
VGNC:4683
736974
Macaque
ectonucleoside triphosphate diphosphohydrolase 8
704424
Mouse
MGI:1919340
72090
Rat
RGD:1561793
613267
Dog
ectonucleoside triphosphate diphosphohydrolase 8
VGNC:40386
100688937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 8
Macaque
ectonucleoside triphosphate diphosphohydrolase 8
Mouse
Rat
Dog
ectonucleoside triphosphate diphosphohydrolase 8
Publication Statistics
PubMed Score 102.09
PubMed score by year
PubTator Score 25.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title